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Series GSE106801 Query DataSets for GSE106801
Status Public on Oct 22, 2019
Title FoxG1 function in hippocampus
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary The forkhead box transcription factor FoxG1 is known to influence forebrain development by determining regional brain specification as well as by regulating expansion of neuronal progenitors and timing of their differentiation. In the adult brain, FoxG1 is expressed in cortex and hippocampus. In the latter it is involved in postnatal neurogenesis in the dentate gyrus by influencing maintenance of the progenitor pool as well as survival and maturation of postmitotic neurons. In humans, haploinsufficiency of FoxG1 causes the congenital version of the Rett syndrome, a progressive neurologic developmental disorder. We use FoxG1 mutant mice to screen for global changes in mRNA expression after partial loss of FoxG1 protein in hippocampi of six week-old mice. Data analysis points to a specific function for FoxG1 in adult hippocampus besides its known involvement in dentate gyrus neurogenesis. We analyse transcriptional changes in the different CA-fields and show that especially the CA-1 field is influenced by lack of FOXG1 protein. Furthermore, data analysis shows altered expression of genes that have also been implicated in the classical form of the Rett syndrome and other autism spectrum disorders.
Overall design mRNA from four different WT and four different FoxG1cre/+hippocampi was analysed
Contributor(s) Vogel T, Weise S, Hacker C, Arumugam G, Videm P, Backofen R
Citation(s) 30539330
BioProject PRJNA417966
Submission date Nov 13, 2017
Last update date Oct 22, 2019
Contact name Tanja Vogel
Phone 497612035086
Organization name University of Freiburg
Department Institute for Anatomy and Cell Biology
Lab Molecular Embryology
Street address Albertstr. 17
City Freiburg
ZIP/Postal code 79104
Country Germany
Platforms (1)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
Samples (6)
GSM2850507 FoxG1plusplus_hippocampus6wk_Rep1
GSM2850508 FoxG1creplus_hippocampus6wk_Rep1
GSM2850509 FoxG1pluplus_hippocampus6wk_Rep2
SRA SRP124785

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Supplementary file Size Download File type/resource
GSE106801_RAW.tar 1000.0 Kb (http)(custom) TAR (of TXT)
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Raw data are available in SRA
Processed data provided as supplementary file

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