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| Status |
Public on Apr 01, 2023 |
| Title |
High-throughput sequencing and analysis of gene modification regulated by epigenetics modification in adult and old intracerebral hemorrhage rats. [RNA-Seq] |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Here we performed in depth epigenome sequencing and analysis to study the mechanism of high mortality rate of ICH in rat brain. It reveals a systematical transcription activation of mRNA genes enriched in inflammation and immune responses. These genes are clustered to specific genomic loci and regulated by repressive and activation chromatin markers. We show that epigenetic reprogramming responding to ICH in old rat brains differs greatly from that in the adult.
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| |
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| Overall design |
Examination of transcriptome genes in adult (13 mon old) and old (21 mon old) ipsilateral and contralateral brain tissues
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| Contributor(s) |
Xiong X, Yang Q |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Nov 15, 2017 |
| Last update date |
Apr 01, 2023 |
| Contact name |
dong chen |
| Organization name |
ablife
|
| Street address |
GaoXin 2nd Road
|
| City |
wuhan |
| State/province |
Hubei |
| ZIP/Postal code |
430064 |
| Country |
China |
| |
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| Platforms (1) |
| GPL20084 |
Illumina NextSeq 500 (Rattus norvegicus) |
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| Samples (4)
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| This SubSeries is part of SuperSeries: |
| GSE106952 |
High-throughput sequencing and analysis of gene modification regulated by epigenetics modification in adult and old intracerebral hemorrhage rats. |
|
| Relations |
| BioProject |
PRJNA418688 |
| SRA |
SRP125083 |
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