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Series GSE106951 Query DataSets for GSE106951
Status Public on Nov 30, 2020
Title High-throughput sequencing and analysis of gene modification regulated by epigenetics modification in adult and old intracerebral hemorrhage rats. [ChIP-Seq]
Organism Rattus norvegicus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Here we performed in depth epigenome sequencing and analysis to study the mechanism of high mortality rate of ICH in rat brain. It reveals a systematical transcription activation of mRNA genes enriched in inflammation and immune responses. These genes are clustered to specific genomic loci and regulated by repressive and activation chromatin markers. We show that epigenetic reprogramming responding to ICH in old rat brains differs greatly from that in the adult.
 
Overall design Examination of 3 different histone modifications in adult (13 mon old) and old (22 mon old) ipsilateral and contralateral brain tissues,2 different histone modifications in old ipsilateral brain tissues with young plasma and old plasma treatment
 
Contributor(s) Xiong X, Yang Q
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Nov 15, 2017
Last update date Dec 01, 2020
Contact name dong chen
Organization name ablife
Street address GaoXin 2nd Road
City wuhan
State/province Hubei
ZIP/Postal code 430064
Country China
 
Platforms (1)
GPL20084 Illumina NextSeq 500 (Rattus norvegicus)
Samples (56)
GSM2858072 m13_L_H3K27Me3-input-1
GSM2858073 m13_L_H3K27Me3-input-2
GSM2858074 m13_L_H3K27Me3-1
This SubSeries is part of SuperSeries:
GSE106952 High-throughput sequencing and analysis of gene modification regulated by epigenetics modification in adult and old intracerebral hemorrhage rats.
Relations
BioProject PRJNA418687
SRA SRP125084

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE106951_22M_K27_peaks.txt.gz 1.2 Mb (ftp)(http) TXT
GSE106951_22M_K9_peaks.txt.gz 3.3 Mb (ftp)(http) TXT
GSE106951_3M_K27_peaks.txt.gz 924.6 Kb (ftp)(http) TXT
GSE106951_3M_K9_peaks.txt.gz 1.4 Mb (ftp)(http) TXT
GSE106951_m13L_H3K27me3_peaks.txt.gz 3.1 Mb (ftp)(http) TXT
GSE106951_m13L_H3K4me3_peaks.txt.gz 1015.3 Kb (ftp)(http) TXT
GSE106951_m13L_H3K9ac_peaks.txt.gz 1.9 Mb (ftp)(http) TXT
GSE106951_m13R_H3K27me3_peaks.txt.gz 1.4 Mb (ftp)(http) TXT
GSE106951_m13R_H3K4me3_peaks.txt.gz 1000.3 Kb (ftp)(http) TXT
GSE106951_m13R_H3K9ac_peaks.txt.gz 2.6 Mb (ftp)(http) TXT
GSE106951_m21L_H3K27me3_peaks.txt.gz 7.9 Mb (ftp)(http) TXT
GSE106951_m21L_H3K4me3_peaks.txt.gz 940.9 Kb (ftp)(http) TXT
GSE106951_m21L_H3K9ac_peaks.txt.gz 3.0 Mb (ftp)(http) TXT
GSE106951_m21R_H3K27me3_peaks.txt.gz 9.6 Mb (ftp)(http) TXT
GSE106951_m21R_H3K4me3_peaks.txt.gz 1.1 Mb (ftp)(http) TXT
GSE106951_m21R_H3K9ac_peaks.txt.gz 3.3 Mb (ftp)(http) TXT
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