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| Status |
Public on Nov 23, 2017 |
| Title |
MAPK pathway activation abrogates CCR7-mediated migration and prolongs survival to trap dendritic cells in LCH lesions |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Patient lesion and control sorted cells were used, treatment with different inhibitors for MAPK pathways for desired amount of time and then was sorted for CD207
and was used for RNA followed by Cdna amplification and was subjected for gene expression analysis using Affy Chips
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| Overall design |
Gene expression analysis from inhibitor treated and sorted LCH lesion cells to understand how the treatment can change gene regulation
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| Contributor(s) |
Chakraborty R, Har Lim KP |
| Citation(s) |
29263218 |
| Submission date |
Nov 22, 2017 |
| Last update date |
Oct 29, 2018 |
| Contact name |
Carl Allen |
| E-mail(s) |
ceallen@txccc.org
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| Phone |
832-822-4000
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| Organization name |
Texas Children's Cancer Center/Baylor College of Medicine
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| Department |
Pediatrics
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| Lab |
Histiocytosis Program
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| Street address |
6621 Fannin St
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| City |
Houston |
| State/province |
TX |
| ZIP/Postal code |
77030 |
| Country |
USA |
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| Platforms (1) |
| GPL17586 |
[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version] |
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| Samples (12)
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| GSM2863293 |
LCH sorted CD207+, DMSO treated, biological paired sample 1 |
| GSM2863294 |
LCH sorted CD207+, BRAFi treated, biological paired sample 1 |
| GSM2863295 |
LCH sorted CD207+, MEKi treated, biological paired sample 1 |
| GSM2863296 |
LCH sorted CD207+, DMSO treated, biological paired sample 2 |
| GSM2863297 |
LCH sorted CD207+, BRAFi treated, biological paired sample 2 |
| GSM2863298 |
LCH sorted CD207+, MEKi treated, biological paired sample 2 |
| GSM2863299 |
LCH sorted CD207+, DMSO treated, biological paired sample 3 |
| GSM2863300 |
LCH sorted CD207+, BRAFi treated, biological paired sample 3 |
| GSM2863301 |
LCH sorted CD207+, MEKi treated, biological paired sample 3 |
| GSM2863302 |
LCH sorted CD207+, DMSO treated, biological paired sample 4 |
| GSM2863303 |
LCH sorted CD207+, BRAFi treated, biological paired sample 4 |
| GSM2863304 |
LCH sorted CD207+, MEKi treated, biological paired sample 4 |
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| Relations |
| BioProject |
PRJNA419472 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE107254_RAW.tar |
303.0 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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