GEO Accession viewer

NCBI > GEO > Accession Display

Not logged in | Login

GEO help: Mouse over screen elements for information.

Series GSE1077

Query DataSets for GSE1077

Status

Public on Mar 11, 2004

Title

MeHg intervention with PK11195

Organism

Mus musculus

Experiment type

Expression profiling by array

Summary

In this time course pregnant CD-1 (outbred) dams were exposed to MeHg as monomethylmercuric chloride intraperitoneally on 9 d.p.c. The test dose of 5.0 mg/kg MeHg was selected as a dose with an estimated 20% increased risk for encephalopathy in term fetuses, with no evidence of maternal toxicosis. Exposed embryos were co-treated with PK11195, a nontoxic ligand of the mitochondrial peripheral-type benzodiazepine receptor (Bzrp) that effectively suppresses developmental toxicity induced with MeHg. The anticipated remediation with 5.0 mg/kg and 4.0 mg/kg PK11195 is <10% malformations. Sampling intervals ranged from 3.0h to 6.0h post-exposure. All measurements were on RNA from the embryonic forebrain (prosencephalon).
Keywords = time series
Keywords = mercury
Keywords = PK11195
Keywords = embryo
Keywords = Fetal Minamata Disease
Keywords: time-course

Contributor(s)

Knudsen TB, Nemeth KR, Singh AV, Charlap JH

Citation missing

Has this study been published? Please login to update or notify GEO.

Submission date

Feb 26, 2004

Last update date

Mar 02, 2012

Contact name

Thomas B Knudsen

E-mail(s)

singh.amarv@epamail.epa.gov