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| Status |
Public on Jan 14, 2019 |
| Title |
DNA methylation profile of Tasmanian Devil facial tumor biopsies and matched healthy skin and spleen samples, as well as additional nerve tissue, and strain 1 tumor cell line. |
| Organism |
Sarcophilus harrisii |
| Experiment type |
Methylation profiling by high throughput sequencing
|
| Summary |
Purpose: Depict the landscape of epigenetic regulation in Tasmanian devil facial tumor biopsies.
Differential analysis of healthy versus tumor biopsies highlighted 166 candidate genes with different DNA methylation levels in their promoters, which included the tumor-specific hypermethylated promoters of Estrogen Receptor 1 (ESR1) and the transcription factor GATA3.
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| Overall design |
We mapped DNA methylation by reduced representation bisulfite sequencing and analysed epigenetic heterogeneity between healthy and tumor biopsies.
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| Contributor(s) |
Bergthaler A, Popa A, Klughammer J, Kosack L, Bock C |
| Citation(s) |
30645971 |
| |
| Submission date |
Dec 15, 2017 |
| Last update date |
Feb 20, 2019 |
| Contact name |
Andreas Bergthaler |
| Organization name |
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
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| Street address |
Lazarettgasse 14 AKH BT25.3
|
| City |
Vienna |
| ZIP/Postal code |
1090 |
| Country |
Austria |
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| Platforms (1) |
| GPL24394 |
Illumina HiSeq 3000 (Sarcophilus harrisii) |
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| Samples (19)
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| Relations |
| BioProject |
PRJNA422612 |
| SRA |
SRP126868 |
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