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| Status |
Public on Nov 05, 2018 |
| Title |
Microarray analysis of gene expression after suppression of PBRM1 or KDM5C in 786-O VHL+/+ or VHL-/- cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
1. PBRM1 loss elicited very similar transcriptional changes as KDM5C loss;
2. PBRM1 loss, and to a lesser extent KDM5C loss, elicited greater transcriptional response in VHL-/- cells than that in VHL+/+ cells.
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| |
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| Overall design |
PBRM1 or KDM5C were suppressed by shRNA in 786-O cells VHL+/+ or VHL-/- before gene expression in triplicates was compared.
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| |
|
| Contributor(s) |
Liao L, Liu Z, Na J, Niu X, Xu Y, Yan Q, Yang H |
| Citation(s) |
30355451 |
| |
| Submission date |
Dec 18, 2017 |
| Last update date |
Nov 30, 2018 |
| Contact name |
Qin Yan |
| E-mail(s) |
qin.yan@yale.edu
|
| Organization name |
Yale University
|
| Department |
Pathology
|
| Lab |
BML348
|
| Street address |
310 Cedar St
|
| City |
New Haven |
| State/province |
CT |
| ZIP/Postal code |
06520-8023 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL10904 |
Illumina HumanHT-12 V4.0 expression beadchip (gene symbol) |
|
| Samples (18)
|
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| Relations |
| BioProject |
PRJNA422885 |
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