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Status |
Public on Jan 05, 2018 |
Title |
Histone variant H3.3-mediated chromatin remodeling is essential for paternal genome activation in mouse preimplantation embryos |
Organism |
Mus musculus |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
H3.3-mediated paternal chromatin remodeling is essential for the development of preimplantation embryos and the activation of the paternal genome during embryogenesis.
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Overall design |
We collected embryos of WT, mH3.3KD and H3.3-addback at 50h after ICSI (8-cell or 16-cell stage). RNA-seq results confirmed excellent knockdown of both H3.3A and H3.3B mRNAs in mH3.3KD and H3.3-addback embryos.
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Contributor(s) |
Kong Q, Banaszynski LA |
Citation(s) |
29358330 |
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Submission date |
Jan 04, 2018 |
Last update date |
Jun 26, 2019 |
Contact name |
Xiaolei Zhang |
E-mail(s) |
zhangxiaolei217@neau.edu.cn
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Organization name |
Northeast Agricultural University
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Street address |
No.59 Mucai street
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City |
Harbin |
ZIP/Postal code |
150000 |
Country |
China |
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Platforms (1) |
GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
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Samples (3) |
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Relations |
BioProject |
PRJNA428516 |
SRA |
SRP130933 |