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| Status |
Public on Feb 01, 2020 |
| Title |
Comparison of expression profiles of SCD::Keap1F/F and SCD::Keap1F/F::Tie1-Cre mouse pulmonary primary endothelial cells(MPPCECs) |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
This experiment evaluate the expression level of Nrf2 genes transcript in mouse primary endothelial cells of a pathology model mice of Sickle cell disease (SCD). Constitutive activation of Nrf2 in SCD suppresses inflammation and organ injury. In the present study we aim to assess the benefit of specific- cell Nrf2 activation in endothelial ceels exclusively.
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| Overall design |
mRNA profiles of SCD::Keap1F/F and SCD::Keap1F/F::Tie1-Cre of MPPCECs were generated by deep sequencing, in triplicate.
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| Contributor(s) |
Keleku-Lukwete N, Mikiko S, Panda H, Otsuki A, Katsuoka F, Saitou R, Saigusa D, Uruno A, Yamamoto M |
| Citation(s) |
31015205 |
| |
| Submission date |
Jan 16, 2018 |
| Last update date |
Feb 01, 2020 |
| Contact name |
Masayuki Yamamoto |
| E-mail(s) |
masiyamamoto@med.tohoku.ac.jp
|
| Phone |
81-22-717-8084
|
| Organization name |
Tohoku University Graduate School of Medicine
|
| Department |
Medical Biochemistry
|
| Street address |
2-1 Seiryo-machi, Aoba-ku
|
| City |
Sendai |
| ZIP/Postal code |
980-8575 |
| Country |
Japan |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA430247 |
| SRA |
SRP131019 |
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