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| Status |
Public on Jan 30, 2018 |
| Title |
Gene Expression during Panobinostat Dosing |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
A clinical study evaluating the dosing of an oral HDACi panobinostat in patient infected with HIV-1. Dosing was 20 mg orally, 3 times weekly, every other week for a total of 8 weeks.
Gene expression was evaluated in whole PBMCs at baseline (Visit 2), after 3 doses (Visit 4), 4 weeks after dosing (Visit 12) and 6 months after dosing (Visit 13) using the Affymetrix HTA 2.0 gene expression chip
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| Overall design |
PBMC's were isolated from EDTA blood tubes by Ficoll separation on the indicated visits. Five million cells were lysed directly in PAX-tubes as recommended by manufacturer. Cell lysate was stored at -80C until RNA extraction was performed
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| Contributor(s) |
Tolstrup M, Falkesgaard J |
| Citation(s) |
29468194 |
| Submission date |
Jan 29, 2018 |
| Last update date |
Oct 29, 2018 |
| Contact name |
Martin Tolstrup |
| Organization name |
Aarhus University
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| Department |
Department of Clinical Medicine
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| Street address |
Palle Juul-Jensens Boulevard 99
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| City |
Aarhus |
| State/province |
DK |
| ZIP/Postal code |
8200 |
| Country |
Denmark |
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| Platforms (1) |
| GPL17586 |
[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version] |
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| Samples (60)
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| GSM2967400 |
PBMC at Visit 13, ID 01 |
| GSM2967401 |
PBMC at baseline, ID 02 |
| GSM2967402 |
PBMC at Visit 4, ID 02 |
| GSM2967403 |
PBMC at Visit 12, ID 02 |
| GSM2967404 |
PBMC at Visit 13, ID 02 |
| GSM2967405 |
PBMC at baseline, ID 04 |
| GSM2967406 |
PBMC at Visit 4, ID 04 |
| GSM2967407 |
PBMC at Visit 12, ID 04 |
| GSM2967408 |
PBMC at Visit 13, ID 04 |
| GSM2967409 |
PBMC at baseline, ID 05 |
| GSM2967410 |
PBMC at Visit 4, ID 05 |
| GSM2967411 |
PBMC at Visit 12, ID 05 |
| GSM2967412 |
PBMC at Visit 13, ID 05 |
| GSM2967413 |
PBMC at baseline, ID 06 |
| GSM2967414 |
PBMC at Visit 4, ID 06 |
| GSM2967415 |
PBMC at Visit 12, ID 06 |
| GSM2967416 |
PBMC at Visit 13, ID 06 |
| GSM2967417 |
PBMC at baseline, ID 07 |
| GSM2967418 |
PBMC at Visit 4, ID 07 |
| GSM2967419 |
PBMC at Visit 12, ID 07 |
| GSM2967420 |
PBMC at Visit 13, ID 07 |
| GSM2967421 |
PBMC at baseline, ID 08 |
| GSM2967422 |
PBMC at Visit 4, ID 08 |
| GSM2967423 |
PBMC at Visit 12, ID 08 |
| GSM2967424 |
PBMC at Visit 13, ID 08 |
| GSM2967425 |
PBMC at baseline, ID 09 |
| GSM2967426 |
PBMC at Visit 4, ID 09 |
| GSM2967427 |
PBMC at Visit 12, ID 09 |
| GSM2967428 |
PBMC at Visit 13, ID 09 |
| GSM2967429 |
PBMC at baseline, ID 10 |
| GSM2967430 |
PBMC at Visit 4, ID 10 |
| GSM2967431 |
PBMC at Visit 12, ID 10 |
| GSM2967432 |
PBMC at Visit 13, ID 10 |
| GSM2967433 |
PBMC at baseline, ID 12 |
| GSM2967434 |
PBMC at Visit 4, ID 12 |
| GSM2967435 |
PBMC at Visit 12, ID 12 |
| GSM2967436 |
PBMC at Visit 13, ID 12 |
| GSM2967437 |
PBMC at baseline, ID 14 |
| GSM2967438 |
PBMC at Visit 4, ID 14 |
| GSM2967439 |
PBMC at Visit 12, ID 14 |
| GSM2967440 |
PBMC at Visit 13, ID 14 |
| GSM2967441 |
PBMC at baseline, ID 15 |
| GSM2967442 |
PBMC at Visit 4, ID 15 |
| GSM2967443 |
PBMC at Visit 12, ID 15 |
| GSM2967444 |
PBMC at Visit 13, ID 15 |
| GSM2967445 |
PBMC at baseline, ID 17 |
| GSM2967446 |
PBMC at Visit 4, ID 17 |
| GSM2967447 |
PBMC at Visit 12, ID 17 |
| GSM2967448 |
PBMC at Visit 13, ID 17 |
| GSM2967449 |
PBMC at baseline, ID 18 |
| GSM2967450 |
PBMC at Visit 4, ID 18 |
| GSM2967451 |
PBMC at Visit 12, ID 18 |
| GSM2967452 |
PBMC at Visit 13, ID 18 |
| GSM2967453 |
PBMC at baseline, ID 19 |
| GSM2967454 |
PBMC at Visit 4, ID 19 |
| GSM2967455 |
PBMC at Visit 12, ID 19 |
| GSM2967456 |
PBMC at Visit 13, ID 19 |
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| Relations |
| BioProject |
PRJNA432059 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE109792_RAW.tar |
1.4 Gb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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