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Status |
Public on Feb 09, 2018 |
Title |
Relationship between tolerance and persistence mechanisms in Acinetobacter baumannii strains with AbkAB Toxin-Antitoxin system |
Organism |
Acinetobacter baumannii |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
Unknown are the mechanisms of tolerance and persistence associated to several compounds in A.baumannii clinical isolates. Using transcriptomical and microbiological studies, we found a link between bacterial tolerance mechanisms to clorhexidine as well as the development of persistence in presence of imipenem in an A.baumannii strain belonging to ST-2 clinical clone (carbapenem-resistant with OXA-24 ß-lactamase and AbkAB TA system by plasmid). Interestingly, in A.baumannii ATCC17978 strain (carbapenem-susceptible isolate which carries AbkAB TA system by plasmid) showed persistence in presence of imipenem.
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Overall design |
Medium of four replicates (4 samples and 4 controls) from RNA of the Ab-2_clon_2010 strain (belonging ST-2 clone) x 1 condition (exposure to CHLX). Statistical analysis by DESeq2 and EdgeR
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Contributor(s) |
Fernández-García L, Fernandez-Cuenca F, Tomás M, Blasco L, López-Rojas R, López M, Bou G, Pascual Á |
Citation(s) |
29463538 |
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Submission date |
Feb 06, 2018 |
Last update date |
May 11, 2018 |
Contact name |
Maria Tomas-Carmona |
E-mail(s) |
ma.del.mar.tomas.carmona@sergas.es
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Organization name |
Instituto de Investigación Biomédica de A Coruña (INIBIC) / Complexo Hospitalario Universitario de A Coruña (CHUAC)
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Department |
Microbiology Department
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Street address |
As Xubias, 84
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City |
A Coruña |
ZIP/Postal code |
15006 |
Country |
Spain |
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Platforms (1) |
GPL24588 |
454 GS FLX Titanium (Acinetobacter baumannii) |
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Samples (8)
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Relations |
BioProject |
PRJNA433173 |
SRA |
SRP132282 |