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Series GSE110207 Query DataSets for GSE110207
Status Public on Feb 09, 2018
Title Relationship between tolerance and persistence mechanisms in Acinetobacter baumannii strains with AbkAB Toxin-Antitoxin system
Organism Acinetobacter baumannii
Experiment type Expression profiling by high throughput sequencing
Summary Unknown are the mechanisms of tolerance and persistence associated to several compounds in A.baumannii clinical isolates. Using transcriptomical and microbiological studies, we found a link between bacterial tolerance mechanisms to clorhexidine as well as the development of persistence in presence of imipenem in an A.baumannii strain belonging to ST-2 clinical clone (carbapenem-resistant with OXA-24 ß-lactamase and AbkAB TA system by plasmid). Interestingly, in A.baumannii ATCC17978 strain (carbapenem-susceptible isolate which carries AbkAB TA system by plasmid) showed persistence in presence of imipenem.
 
Overall design Medium of four replicates (4 samples and 4 controls) from RNA of the Ab-2_clon_2010 strain (belonging ST-2 clone) x 1 condition (exposure to CHLX). Statistical analysis by DESeq2 and EdgeR
 
Contributor(s) Fernández-García L, Fernandez-Cuenca F, Tomás M, Blasco L, López-Rojas R, López M, Bou G, Pascual Á
Citation(s) 29463538
Submission date Feb 06, 2018
Last update date May 11, 2018
Contact name Maria Tomas-Carmona
E-mail(s) ma.del.mar.tomas.carmona@sergas.es
Organization name Instituto de Investigación Biomédica de A Coruña (INIBIC) / Complexo Hospitalario Universitario de A Coruña (CHUAC)
Department Microbiology Department
Street address As Xubias, 84
City A Coruña
ZIP/Postal code 15006
Country Spain
 
Platforms (1)
GPL24588 454 GS FLX Titanium (Acinetobacter baumannii)
Samples (8)
GSM2982229 IonXpressRNA001
GSM2982230 IonXpressRNA002
GSM2982231 IonXpressRNA003
Relations
BioProject PRJNA433173
SRA SRP132282

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE110207_Ab-_2_clon_2010Contig_all_protein.fa.tsv.gz 793.8 Kb (ftp)(http) TSV
GSE110207_Diffexpr-results_DESeq.csv.gz 203.1 Kb (ftp)(http) CSV
GSE110207_EdgeR_Common_Dispersion.csv.gz 136.7 Kb (ftp)(http) CSV
GSE110207_EdgeR_GLM.csv.gz 136.8 Kb (ftp)(http) CSV
GSE110207_IonXpress_results_HTSEQ_.csv.gz 62.9 Kb (ftp)(http) CSV
GSE110207_Lista_genes_DESEQ2_edgeR.txt.gz 38.1 Kb (ftp)(http) TXT
GSE110207_SigDownReg-DESeq.csv.gz 98.7 Kb (ftp)(http) CSV
GSE110207_SigGenes_DESeq_edgeR.csv.gz 38.3 Kb (ftp)(http) CSV
GSE110207_SigUpReg-DESeq.csv.gz 98.7 Kb (ftp)(http) CSV
GSE110207_cds_Ab-_2_clon_2010Contig_nt.fasta.gz 1.2 Mb (ftp)(http) FASTA
GSE110207_gen_annotation_plasmid_Ab-2_clon_2010_Plasmid.xls.gz 13.3 Kb (ftp)(http) XLS
GSE110207_gene_annotation_genomic_Ab-2_clon_2010_Genes.xls.gz 292.3 Kb (ftp)(http) XLS
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Raw data are available in SRA
Processed data are available on Series record

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