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Series GSE11028 Query DataSets for GSE11028
Status Public on Dec 03, 2009
Title Duck versus Chicken
Platform organisms Gallus gallus; Homo sapiens; Mus musculus
Sample organisms Anas platyrhynchos; Gallus gallus
Experiment type Expression profiling by array
Summary Avian beaks show extreme species-specific variability in morphology, though they develop from the same primordial structures. In both humans and birds, cranial neural crest cells are the primary source of mesenchyme for the frontonasal prominence; previous work has shown that these cells contain molecular information that regulate species-specific facial variation. To determine the molecular basis of avian craniofacial patterning, we have gene expression profiled micro-dissected cranial neural crest cells from the frontonasal prominence of three bird species (chickens, quails, and ducks) during embryonic development. These changes in gene expression were measured on a custom built, cross-species, long oligonucleotide microarray that interrogates the vast majority of transcription factor (TF) genes plus a wide variety of signaling pathways. Samples were isolated at two developmental stages, before (Hamburger Hamilton stage [HH] 20) and after (HH25) morphological distinctions between the species are evident.
Keywords: cross-species comparison
 
Overall design Frontonasal mesenchymal cells were micro-dissected two developmental stages, before (Hamburger Hamilton stage [HH] 20) and after (HH25) morphological distinctions between the species are evident. For each sample, mesenchyme from 40 embryos was pooled. For each stage-matched comparison between duck and chicken, experiments include technical replicates as well as dye-switches for a total of 14 microarrays.
 
Contributor(s) Powder KE, Brugmann SA, Helms JA, Lovett M
Citation(s) 20015954
Submission date Apr 02, 2008
Last update date Jan 18, 2013
Contact name Kara Powder
E-mail(s) kara.powder@gmail.com
Organization name Washington University in St Louis
Department Genetics
Lab Lovett
Street address 4566 Scott Ave
City Saint Louis
State/province MO
ZIP/Postal code 63108
Country USA
 
Platforms (1)
GPL6648 Lovett/WUSTL 0.7k TFarray v3
Samples (14)
GSM278649 Duck20-Cy3_Chicken20-Cy5_1
GSM278650 Duck20-Cy3_Chicken20-Cy5_2
GSM278651 Duck20-Cy3_Chicken20-Cy5_3
This SubSeries is part of SuperSeries:
GSE11099 Molecular basis of species-specific variation in beak morphology
Relations
BioProject PRJNA108803

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary data files not provided
Processed data not provided for this record

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