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Status |
Public on Feb 23, 2018 |
Title |
Microarray study of tumoral tissue transcriptome of breast cancer in mexican women who are overweight or obese |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
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Summary |
In this work, transcriptoma of invasive breast carcinoma was studied by means of microarray expression in Mexican women who are overweight or obese. The dysfunction of the adipokines signaling pathways has recently been linked to more aggressive features of breast cáncer. We hypothesized that there are changes related to the signaling of adipokines in the expression profile of invasive breast carcinoma of Mexican women with overweight or obesity. The objectives were as follows: 1) Determine the expression profile of tumour tissue of Mexican women who are overweight or obese by comparing tumoral tissue and non -tumoral tissue, both from the same patient, 2) Identification of over- or underexpressed genes involved in signalling pathways related to adipokines and the tumour process, 3) Identify the signalling pathways that presented genes with expression changes and were related to adipokines and the tumoural process.
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Overall design |
Six independent pools: three samples from obese patients, two samples from obese patients, two samples from overweight patients, two samples from overweight patients, three samples from overweight patients, two samples from overweight patients, comprised of total RNA isolated from tumor and adjacent tissue.
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Contributor(s) |
Floriano E, Ignacio I, Cardenas N, Brindis FG, Cordova MG, Comoto DA, Heredia AG, Millan A, Ortiz JL, Arroyo IM, Estrada LE |
Citation missing |
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Submission date |
Feb 22, 2018 |
Last update date |
Mar 27, 2018 |
Contact name |
Esau Floriano Sanchez |
E-mail(s) |
floriano_esa@yahoo.com
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Organization name |
SEDENA
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Department |
Military School of Graduate of Health
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Lab |
Multidisciplinary Research Laboratory
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Street address |
Cerrada de Palomas SN
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City |
Mexico City |
ZIP/Postal code |
11620 |
Country |
Mexico |
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Platforms (1) |
GPL16699 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version) |
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Samples (6)
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GSM3019802 |
CaM2_3: Tumor tissue vs adjacent tissue from obese women |
GSM3019803 |
CaM1_3: Tumor tissue vs adjacent tissue from obese women |
GSM3019804 |
CaM2_2: Tumor tissue vs adjacent tissue from overweight women |
GSM3019805 |
CaM1_2: Tumor tissue vs adjacent tissue from overweight women |
GSM3019806 |
CaM1_1: Tumor tissue vs adjacent tissue from overweight women |
GSM3019807 |
CaM2_1: Tumor tissue vs adjacent tissue from overweight women |
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Relations |
BioProject |
PRJNA435533 |