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Status |
Public on Mar 13, 2018 |
Title |
Functional and genomic characterization of a xenograft model system for the study of metastasis in triple-negative breast cancer |
Organism |
Homo sapiens |
Experiment type |
Genome variation profiling by SNP array
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Summary |
To define the molecular regulators of metastasis of triple-negative breast cancer, we conducted a rigorous characterization of four populations of MDA-MB-231 human triple-negative breast cancer cells that display a range of intrinsic spontaneous metastatic capacities in immuno-deficient mice, from non-metastatic to highly metastatic to lung, liver, spleen and spine. PAT-Seq gene expression profiling of primary tumor cells identified the fibroblast growth factor homologous factor, FGF13, as a candidate metastatic virulence gene highly upregulated in aggressively metastatic MDA-MB-231HM tumors.
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Overall design |
SNP analysis from of 4 increasingly metastatic breast cancer tumour cell lines
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Contributor(s) |
Johnstone CN, Pattison AD, Harrison PF, Powell DR, Lock P, Anderson RL, Beilharz TH |
Citation(s) |
29720474 |
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Submission date |
Mar 12, 2018 |
Last update date |
May 09, 2018 |
Contact name |
Andrew Pattison |
E-mail(s) |
andrew.pattison@monash.edu
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Organization name |
Monash University
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Street address |
Wellington Rd
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City |
Melbourne |
State/province |
Vic |
ZIP/Postal code |
3800 |
Country |
Australia |
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Platforms (1) |
GPL13829 |
Illumina HumanCytoSNP-12 v2.1 BeadChip |
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Samples (4)
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This SubSeries is part of SuperSeries: |
GSE111706 |
Metastasis in triple-negative breast cancer |
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Relations |
BioProject |
PRJNA437934 |