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Series GSE111730 Query DataSets for GSE111730
Status Public on Mar 28, 2018
Title RNA-seq of bone marrow derived macrophages stimulated with monophosphoryl lipid A (MPLA)
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We found that MPLA reprograms macrophages in a way that supports a persistent monocyte/macrophage chemokine secretion profile reflected in macrophage mRNA. Additionally, this RNA-seq data revealed that certain genes (e.g. phagocytosis-related) persist much longer after MPLA than others (e.g. pro-inflammatory cytokines).
Overall design Bone marrow derived macrophages were harvested for RNA after 4hrs of monophosphoryl lipid A (MPLA) priming, 24hrs of MPLA priming, and 3 days following the end of priming
Contributor(s) Fensterheim BA, Bohannon JK
Citation(s) 29686054
Submission date Mar 12, 2018
Last update date Feb 11, 2019
Contact name Benjamin Ari Fensterheim
Phone 3012375083
Organization name Vanderbilt University
Department Pathology, Microbiology, and Immunology
Lab Sherwood Lab
Street address 1161 21st Avenue South
City Nashville
State/province TN
ZIP/Postal code 37232
Country USA
Platforms (1)
GPL21493 Illumina HiSeq 3000 (Mus musculus)
Samples (12)
GSM3038526 Control 1
GSM3038527 Control 2
GSM3038528 Control 3
BioProject PRJNA437979
SRA SRP134976

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Supplementary file Size Download File type/resource
GSE111730_MultiRankSeq_123_vs_101112.html.diff.csv.gz 2.0 Mb (ftp)(http) CSV
GSE111730_MultiRankSeq_123_vs_456.html.diff.csv.gz 1.8 Mb (ftp)(http) CSV
GSE111730_MultiRankSeq_123_vs_789.html.diff.csv.gz 1.9 Mb (ftp)(http) CSV
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