|
| Status |
Public on Apr 04, 2019 |
| Title |
Functional proteomics identified an upstream trancription complex promoting piRNA biogenesis |
| Organism |
Caenorhabditis elegans |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Here we used functional proteomics approaches to identify an upstream transcription complex (USTC) that is required for piRNA biogenesis. The complex contains PRDE-1, SNPC-4, TOFU-4, and TOFU-5, all of which are enriched on the two piRNA clusters on chromosome IV and form distinct piRNA foci in the nucleus.
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| |
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| Overall design |
Examination of functional role of a newly discovered complex in piRNA biogenesis
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| |
|
| Contributor(s) |
Miska E, Ahringer J, Guang S |
| Citation missing |
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| Submission date |
Apr 04, 2018 |
| Last update date |
Apr 05, 2019 |
| Contact name |
Eric Miska |
| E-mail(s) |
eam29@cam.ac.uk
|
| Organization name |
University of Cambridge
|
| Department |
The Gurdon Institute
|
| Lab |
Eric Miska Lab
|
| Street address |
tennis court road
|
| City |
cambridge |
| ZIP/Postal code |
CB2 1QN |
| Country |
United Kingdom |
| |
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| Platforms (1) |
| GPL18730 |
Illumina HiSeq 1500 (Caenorhabditis elegans) |
|
| Samples (5)
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| Relations |
| BioProject |
PRJNA448738 |
| SRA |
SRP137094 |
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