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Series GSE113079 Query DataSets for GSE113079
Status Public on Aug 17, 2019
Title LncRNA Expression Profile and Identification of Novel LncRNA Biomarkers for Diagnosing Coronary Artery Disease
Organism Homo sapiens
Experiment type Non-coding RNA profiling by array
Summary Dysregulation of long non-coding RNAs (lncRNAs) has been proven to be involved in the pathogenesis of coronary artery disease (CAD). However, it remains to be extensively explored.Using microarray, we performed the transcriptome-wide lncRNA and mRNAs expression profile in peripheral blood mononuclear cells (PBMCs) of 93 CAD patients and 48 healthy controls. Gene Ontology (GO) and pathway analysis for differentially expressed mRNAs was used to investigate underlying biological associations of differentially expressed lncRNAs and create path-net to depict interactions of significant pathways. We identified 1,210 lncRNAs and 890 mRNAs differentially expressed from the expression profile and validated selected 7 lncRNAs. Two novel lncRNA biomarkers, ENST00000444488.1 and uc010yfd.1, together with CAD risk factors had the better predictive performance for discriminating CAD patients from healthy controls, and ENST00000444488.1 could diagnose acute myocardial infarction (AMI) patients from non-AMI patients.
 
Overall design 93 Coronary Artery Disease patients and 48 healthy controls
 
Contributor(s) Li L, Wang L
Citation(s) 30015300, 34868268
Submission date Apr 12, 2018
Last update date Dec 14, 2021
Contact name Lin Li
E-mail(s) lilinshine@163.com
Organization name Department of Epidemiology, State Key Laboratory of Cardiovascular Disease
Department Department of Epidemiology
Lab State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases
Street address Xicheng District, No.167 Beilishi Road
City Beijing
State/province Beijing
ZIP/Postal code 100037
Country China
 
Platforms (1)
GPL20115 Agilent-067406 Human CBC lncRNA + mRNA microarray V4.0 (Probe name version)
Samples (141)
GSM3095926 Peripheral Blood Mononuclear Cells,CAD patient 1
GSM3095927 Peripheral Blood Mononuclear Cells,CAD patient 2
GSM3095928 Peripheral Blood Mononuclear Cells,CAD patient 3
Relations
BioProject PRJNA449934

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE113079_RAW.tar 1.2 Gb (http)(custom) TAR (of JPG, TXT)
Processed data included within Sample table

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