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Status |
Public on Sep 04, 2008 |
Title |
Molecular subtypes of DLBCL have distinct chromosomal aberrations |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array Genome variation profiling by genome tiling array
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Summary |
We performed array comparative genomic hybridization (aCGH) and gene expression profiling in 203 samples of diffuse large B cell lymphoma (DLBCL). By gene expression, at least three molecular subtypes of DLBCL termed as germinal center B cell-like (GCB) DLBCL, activated B cell-like (ABC) DLBCL, and primary mediastinal B cell lymphoma (PMBL) can be distinguished. Combining gene expression profiling and aCGH, revealed copy number abnormalities that had strikingly different frequencies in the three molecular DLBCL subtypes. These data provide genetic evidence that the DLBCL subtypes are distinct diseases that utilize different oncogenic pathways. Keywords: clinical history design
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Overall design |
The retrospective study included RNA and DNA extracted from 203 clinical samples.
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Citation(s) |
18765795 |
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Submission date |
May 01, 2008 |
Last update date |
Mar 25, 2019 |
Contact name |
Louis M. Staudt |
E-mail(s) |
lstaudt@mail.nih.gov
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Phone |
301-402-1892
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Organization name |
National Cancer Institute
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Department |
Lymphoid Malignancies Branch
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Lab |
Louis M Staudt
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Street address |
9000 Rockville Pike, Bldg 10, Rm 4N114
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City |
Bethesda |
State/province |
MD |
ZIP/Postal code |
20892 |
Country |
USA |
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Platforms (2) |
GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
GPL6400 |
NCI NimbleGen Homo sapiens HG17 Whole Genome 385K Tiling Set version 1 |
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Samples (406)
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Relations |
BioProject |
PRJNA106631 |