|
| Status |
Public on Apr 27, 2020 |
| Title |
Gene expression data from study on the role of DISC1 607 variants on immune responses against Toxoplasma gondii |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
A major mental illness-related susceptibility factor, Disrupted in schizophrenia (DISC1), is involved in altered host immune responses against Toxoplasma gondii (T. gondii) infection. Specifically, our gene expression studies have revealed that DISC1 Leu607Phe variation, which changes DISC1 interaction with activating transcription factor 4 (ATF4), modifies gene expression patterns upon T. gondii infection.
|
| |
|
| Overall design |
EBV-transformed human lymphoblastoid cells with DISC1 607 Leu/Leu and Phe/Phe genotypes were infected with T. gondii for 48 hours. Cells were harvested and total RNA was isolated by Qiagen RNEasy kit. Genee expression profiling was conducted with Illumina HT-12 v4.0 platform at the Microarray Core Facility at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University.
|
| |
|
| Contributor(s) |
Kano S, Sawa A |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Apr 27, 2018 |
| Last update date |
Apr 29, 2020 |
| Contact name |
Shinichi Kano |
| Organization name |
University of Alabama at Birmingham
|
| Department |
Psychiatry
|
| Street address |
1720 7th Ave South
|
| City |
Birmingham |
| State/province |
AL |
| ZIP/Postal code |
35233 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL10904 |
Illumina HumanHT-12 V4.0 expression beadchip (gene symbol) |
|
| Samples (12)
|
|
| Relations |
| BioProject |
PRJNA454014 |
Less...
More...