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Series GSE114082 Query DataSets for GSE114082
Status Public on May 21, 2019
Title Gene expression profiling of primary HER2-positive breast cancers before and after brief exposure to single agent neoadjuvant trastuzumab
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Tumor incisional biopsies were obtained at baseline and after brief-exposure to single-agent trastuzumab from patients enrolled on the TRastuzumab-UPfront-in-HER2-positive-locally-advanced- BC (TRUP) window-of-opportunity trial. Gene expression profiling was conducted on these tumor biopsies to identify transcriptional features at baseline and changes upon brief-exposure to trastuzumab associated with response to short term trastuzumab and the complete pre-operative therapy
 
Overall design Gene expression profiling was performed using RNA from frozen core biopsies from 17 patients with primary HER2-positive (HER2+) tumors before and after brief-exposure treatment with single agent neoadjuvant trastuzumab.
 
Contributor(s) De Cecco L, Triulzi T
Citation(s) 30478407
Submission date May 06, 2018
Last update date May 21, 2019
Contact name Loris De Cecco
E-mail(s) loris.dececco@istitutotumori.mi.it
Organization name IRCSS Istituto Nazionale Tumori
Street address via Venezian 1
City Milan
ZIP/Postal code 20133
Country Italy
 
Platforms (1)
GPL14951 Illumina HumanHT-12 WG-DASL V4.0 R2 expression beadchip
Samples (34)
GSM3132496 1_Pre
GSM3132497 1_Post
GSM3132498 2_Pre
Relations
BioProject PRJNA464245

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE114082_Clinical_characteristics.pdf 180.1 Kb (ftp)(http) PDF
GSE114082_non-normalized.txt.gz 5.6 Mb (ftp)(http) TXT
Processed data included within Sample table

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