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| Status |
Public on Dec 26, 2018 |
| Title |
CARM1 (PRMT4) acts as a transcriptional coactivator during retinoic acid-induced embryonic stem cell differentiation |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Our data demonstrate that CARM1 is required for transcriptional activation of a subset of retinoic acid (RA) target genes in J1 murine embryonic stem cells
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| Overall design |
To address CARM1 function during RA-induced differentiation of murine embryonic stem cells (mESCs), we treated WT (wild-type), shCtl (scramble control), and CARM1 knockdown (KD) ESCs with vehicle (EtOH) or 1μM Retinoic Acid (RA) for 48hrs and performed expression profiling by RNA-seq
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| |
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| Contributor(s) |
Quintero CM, Laursen KB, Mongan NP, Luo M, Gudas LJ |
| Citation(s) |
30153436 |
| |
| Submission date |
Jun 14, 2018 |
| Last update date |
Mar 21, 2019 |
| Contact name |
Kristian Laursen |
| E-mail(s) |
krl2004@med.cornell.edu
|
| Phone |
2127466254
|
| Organization name |
Weill Cornell Medicine
|
| Department |
Pharmacology
|
| Lab |
Gudas Lab
|
| Street address |
1300 York Ave.
|
| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10065 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA476131 |
| SRA |
SRP150542 |
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