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| Status |
Public on Nov 19, 2018 |
| Title |
Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells |
| Organism |
Macaca mulatta |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Innate lymphoid cells (ILCs) play critical roles in mucosal barrier defense and tissue homeostasis. While ILCs are depleted in HIV-1 infection, this phenomenon is not a generalized feature of all viral infections. Here we show in untreated SIV-infected rhesus macaques (RMs) that ILC3s are lost rapidly in mesenteric lymph nodes (MLN) yet preserved in SIV+ RMs with pharmacologic or natural control of viremia. In healthy uninfected RMs, experimental depletion of CD4+ T cells in combination with DSS is sufficient to reduce ILC frequencies in the MLN. In this setting and in chronic SIV+ RMs, IL-7R alpha chain expression diminishes on ILC3s in contrast to the IL-18R alpha chain expression which remains stable. In HIV-uninfected patients with durable CD4+ T cell deficiency, deemed idiopathic CD4+ lymphopenia, similar ILC deficiencies in blood were observed, collectively identifying determinants of ILC homeostasis in primates and potential mechanisms underlying their depletion in HIV/SIV infection.
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| Overall design |
There are 12 samples, 3 healthy, 8 SIV infected of which there are 4 acute and 4 chronic SIV infected.
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| Contributor(s) |
Mudd JC, Busman-Sahay K, DiNapoli SR, Lai S, Sheik V, Lisco A, Deleage C, Richardson B, Palesch D, Paiardini M, Cameron M, Sereti I, Reeves K, Estes JD, Brenchley JM, Wilkinson PA |
| Citation(s) |
30262807 |
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| Submission date |
Jun 19, 2018 |
| Last update date |
Jan 07, 2020 |
| Contact name |
Peter A Wilkinson |
| Organization name |
Case Western Reserve University
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| Department |
Pathology / Systems Biology & Bioinformatics
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| Street address |
2103 Cornell Road
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| City |
Cleveland |
| State/province |
Ohio |
| ZIP/Postal code |
44120 |
| Country |
USA |
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| Platforms (1) |
| GPL19129 |
Illumina HiSeq 2500 (Macaca mulatta) |
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| Samples (11)
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| Relations |
| BioProject |
PRJNA476787 |
| SRA |
SRP150871 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE116013_counts.csv.gz |
425.1 Kb |
(ftp)(http) |
CSV |
| GSE116013_counts.normalized.csv.gz |
931.5 Kb |
(ftp)(http) |
CSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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