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Status |
Public on Dec 27, 2018 |
Title |
A-485 induce significant decrease in MITF and MITF signature genes in melanoma cell lines. |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
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Summary |
Differential response to p300 inhibitor A-485 was observed in a panel of melanoma cell lines. Three melanoma cell lines were treated with A-485 and microarray was used to determine gene expession changes at 6 and 24 hours.
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Overall design |
Melanoma cell lines, two sensitive and one resistant cell lines, were treated with A-485 to identify genes that are differentially modulated by A-485.
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Contributor(s) |
Hessler P, Lam L |
Citation(s) |
- Wang R, He Y, Robinson V, Yang Z et al. Targeting Lineage-specific MITF Pathway in Human Melanoma Cell Lines by A-485, the Selective Small-molecule Inhibitor of p300/CBP. Mol Cancer Ther 2018 Dec;17(12):2543-2550. PMID: 30266801
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Submission date |
Jun 29, 2018 |
Last update date |
Mar 25, 2019 |
Contact name |
Xin Lu |
E-mail(s) |
xin.x.lu@abbvie.com
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Phone |
847-937-7942
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Organization name |
Abbvie
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Department |
Oncology Discovery
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Street address |
1 North Waukegan Rd
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City |
North Chicago |
State/province |
IL |
ZIP/Postal code |
60064 |
Country |
USA |
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Platforms (1) |
GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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Samples (18)
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Relations |
BioProject |
PRJNA478559 |