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Series GSE116626 Query DataSets for GSE116626
Status Public on Sep 13, 2020
Title Specific biomarkers Associated with Active and Chronic Renal Lesions in IgA Nephropathy. A Multicenter Study
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Specific molecular biomarkers were detected in kidney biopsy of IgA nephropathy characterizing active (E and C) and chronic (T) renal lesions compared with other non-IgA glomerulonephritis and living donors
 
Overall design RNA was extracted from archival FFPE biopsy samples of 52 IgAN patients, 22 non-IgAN glomerulonephritis (non-IgAN GN) and 7 kidney living donors (LD). Genome-wide gene expression profiles were generated and stringent statistical analysis identified transcripts associated with active and chronic renal lesions. gAN patients were scored using the MEST-C classification by three pathologists (MR, BMA, CG) and stratified into 4 groups with different composite renal lesions: minimal N.22 (M0,1; E0; S0,1; T0; C0); active N. 8 (M0,1; S0,1; T0; E1 and/or C,1,2); chronic N:12 (M0,1; E0; S0,1; T1,2; C0); mixed group of active and chronic lesions N.10(M0,1; E0,1; S0,1; T1,2; C0,1,2).
Web link https://www.nature.com/articles/s41598-020-72026-2
 
Contributor(s) Cox SN, Chiurlia S, Divella C, Rossini M, Schena FP, Zaza G
Citation(s) 32938960
Submission date Jul 04, 2018
Last update date Sep 25, 2020
Contact name Sharon Natasha Cox
E-mail(s) sharonnatasha.cox@gmail.com
Organization name Schena Foundation
Department Renal Lab
Street address Strada Provinciale Valenzano-Casamassima-Km3
City Valenzano-Bari
ZIP/Postal code 70010
Country Italy
 
Platforms (1)
GPL14951 Illumina HumanHT-12 WG-DASL V4.0 R2 expression beadchip
Samples (81)
GSM3244301 minimal_lesion_IgAN_1
GSM3244302 minimal_lesion_IgAN_2
GSM3244303 minimal_lesion_IgAN_3
Relations
BioProject PRJNA479685

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE116626_non_normalized.txt.gz 12.6 Mb (ftp)(http) TXT
Processed data included within Sample table

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