|
| Status |
Public on Jul 11, 2018 |
| Title |
Gene expression profile difference among renal location in a stone former |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Comparison between renal papilla tissue with and without the presence of calcified Randall’s plaques, and between the papilla, medulla, and cortex regions from within a single recurrent stone forming kidney demonstrated that patterns of gene expression between the papilla, medulla, and cortex that distinguished these three regions from one another. Disease and function analysis of these gene sets demonstrated up-regulation of genes related to urinary/renal disorders, granulocyte response, vascular smooth muscle cell proliferation, dehydration, and renal calcification and down-regulation of genes related to carboxylic acid/ lipid/ fatty acid transport and urine osmolality.
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| |
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| Overall design |
Specimen: Needle core biopsy specimens from a recurrent CaOx stone kidney. RNA-sequence was performed by the Illumina HiSeq 4000.
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| |
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| Contributor(s) |
Taguchi K, Chi T |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Jul 10, 2018 |
| Last update date |
Mar 21, 2019 |
| Contact name |
Kazumi Taguchi |
| E-mail(s) |
ktaguchi@med.nagoya-cu.ac.jp
|
| Organization name |
Nagoya City University Graduate School of Medical Sciences
|
| Department |
Nephro-urology
|
| Street address |
Kawasumi-1, Mizuho-cho, Mizuho-ku
|
| City |
Nagoya |
| ZIP/Postal code |
4678601 |
| Country |
Japan |
| |
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| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA480454 |
| SRA |
SRP152942 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE116860_All_genes.Chi_0660.txt.gz |
6.3 Mb |
(ftp)(http) |
TXT |
| GSE116860_DE_heatmap_nosymbols_euclidean-average.png.gz |
127.9 Kb |
(ftp)(http) |
PNG |
| GSE116860_Log.STARHUMAN.txt.gz |
1.3 Kb |
(ftp)(http) |
TXT |
| GSE116860_Tissue-cortexvsmedula.pdf |
191.3 Kb |
(ftp)(http) |
PDF |
| GSE116860_Tissue-cortexvsmedula.png.gz |
111.6 Kb |
(ftp)(http) |
PNG |
| GSE116860_Tissue-cortexvspapilla.pdf |
308.3 Kb |
(ftp)(http) |
PDF |
| GSE116860_Tissue-cortexvspapilla.png.gz |
214.4 Kb |
(ftp)(http) |
PNG |
| GSE116860_Tissue-papillavsmedula.pdf |
162.1 Kb |
(ftp)(http) |
PDF |
| GSE116860_Tissue-papillavsmedula.png.gz |
118.1 Kb |
(ftp)(http) |
PNG |
| GSE116860_counts.STARHUMAN.txt.gz |
732.4 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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