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| Status |
Public on Jul 01, 2021 |
| Title |
Identification of differentially expressed miRNAs in exosomes secreted from human colon cancer stem cells. |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by high throughput sequencing
|
| Summary |
As accumulating evidence suggests cancer cells exhibit stem-like properties for advanced diseases and cancer stem cells (CSCs) have been identified in various tumor types, revisiting present knowledge toward CSCs is essential. The identification of exosome-loaded miRNAs responsible for stemness and chemoradioresistance of CSCs should eventually leadd to development of novel therapeutic approaches.
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| |
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| Overall design |
Expression profiles of miRNAs of purified exosomes from parental HCT15/29 cells and HCT15/29-derived cancer spheres were generated for identifying central miRNAs for CSC malignancy.
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| Contributor(s) |
Cheng W, Hwang W |
| Citation(s) |
30980673 |
| |
| Submission date |
Jul 23, 2018 |
| Last update date |
Nov 29, 2021 |
| Contact name |
Wei-Chung Cheng |
| E-mail(s) |
cwc0702@gmail.com
|
| Organization name |
China Medical University
|
| Street address |
No.91, Hsueh-Shih Road
|
| City |
Taichung |
| ZIP/Postal code |
40402 |
| Country |
Taiwan |
| |
|
| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
|
| Samples (4)
|
| GSM3301691 |
The miRNA profile of exosomes from parental HCT15 cells. |
| GSM3301692 |
The miRNA profile of exosomes from HCT15-derived spheres. |
| GSM3301693 |
The miRNA profile of exosomes from parental HCT29 cells. |
| GSM3301694 |
The miRNA profile of exosomes from HCT29-derived spheres. |
|
| Relations |
| BioProject |
PRJNA482307 |
| SRA |
SRP154830 |
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