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Series GSE119958 Query DataSets for GSE119958
Status Public on Sep 15, 2018
Title APOL1 renal-risk variants induce mitochondrial fission
Organism Homo sapiens
Experiment type Expression profiling by array
Summary To assess gene expression by APOL1 genotypes in primary proximal tubule cells (PTCs), global gene expression (mRNA) levels were examined on Affymetrix HTA 2.0 arrays in primary PTCs cultured from non-diseased kidney in African Americans without CKD who underwent nephrectomy for localized renal cell carcinoma.
 
Overall design To detect gene profiles attributable to APOL1 renal-risk genotypes, African American primary proximal tubule cells with two APOL1 renal-risk alleles (N=5), one risk allele (N=23), and lacking renal-risk alleles (N=22) were compared for global gene expression when poly IC stimulation was absent (pre-) or present (post-) .
 
Contributor(s) Ma L, Ainsworth HC, Snipes JA, Murea M, Choi YA, Langefeld CD, Parks JS, Bharadwaj MS, Chou JW, Hemal AK, Petrovic S, Craddock AL, Cheng D, Hawkins G, Miller L, Hicks PJ, Saleem MA, Divers J, Molina AJ, Freedman BI
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NIH grant(s)
Grant ID Grant title Affiliation Name
R01 MD009055 Genetic Determinants of Renal Transplant Survival from African American Donors WAKE FOREST UNIVERSITY HEALTH SCIENCES Jasmin Divers
R01 DK070941 An Integrative Genomic Approach to APOL1-Associated Nephropathy. WAKE FOREST UNIVERSITY HEALTH SCIENCES BARRY Ira FREEDMAN
Submission date Sep 14, 2018
Last update date Apr 04, 2020
Contact name Lijun Ma
E-mail(s) lima@wakehealth.edu
Organization name Wake Forest School of Medicine
Department Nephrology
Street address 1 Medical Center Blvd
City Winston Salem
State/province NC
ZIP/Postal code 27157
Country USA
 
Platforms (1)
GPL17586 [HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
Samples (100)
GSM3389407 African American primary proximal tubule cells (K10015_pre)
GSM3389408 African American primary proximal tubule cells (K10018_pre)
GSM3389409 African American primary proximal tubule cells (K10023_pre)
Relations
BioProject PRJNA490827

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE119958_RAW.tar 2.2 Gb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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