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Series GSE120801 Query DataSets for GSE120801
Status Public on May 31, 2020
Title Whole genome non-coding RNA profiling of the developing hippocampus of the Down syndrome mouse model Dp16(1)Yey
Organism Mus musculus
Experiment type Non-coding RNA profiling by high throughput sequencing
Expression profiling by high throughput sequencing
Summary In this study we performed a systematic analysis of the non-coding RNA (ncRNA) transcriptomes of the Down Syndrome (DS) developing hippocampus using the DS mouse model Dp16(1)Yey. DS, caused by the trisomy of chromosome 21 (HSA21) is the most frequent human chromosomal disorder. Hippocampal-dependent learning and memory impairment is one of the most significant deficits of DS. ncRNAs: microRNA (miRNA), long non-coding RNA (lncRNA), and circular RNA (circRNA) have been increasingly revealed to be participating in various biological activities, especially in the brain development and neuronal functions. This study provides a map of the dysregulated lncRNAs and circRNAs in the DS developing hippocampus for the first time.
Overall design Hippocampi were isolated from the postnatal day 7 Dp16(1)Yey pups and their wild-type littermates. Three hippocampi with the same genotype were pooled together. The non-coding RNA profilings of the DS mutant Dp16(1)Yey were compared with the ones of wild-type.
Contributor(s) Jiang X, Cai Z, Xiao Z, Liu H, Liu L
Citation(s) 32946063
Submission date Oct 03, 2018
Last update date Feb 08, 2021
Contact name Xiaoling Jiang
Phone 86-18058712510
Organization name Guangzhou Women and Children's Medical Center
Department Department of Genetics and Endocrinology
Street address 9 Jinsui Road, Tianhe District
City Guangzhou
State/province Guangdong
ZIP/Postal code 510623
Country China
Platforms (2)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
GPL21493 Illumina HiSeq 3000 (Mus musculus)
Samples (6)
GSM3415990 WT pool (circRNA)
GSM3415991 Dp16 pool (circRNA)
GSM3415992 WT pool (miRNA)
BioProject PRJNA494569
SRA SRP163256

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE120801_circRNA_exp.txt.gz 1.1 Mb (ftp)(http) TXT
GSE120801_lncRNA_exp.txt.gz 876.1 Kb (ftp)(http) TXT
GSE120801_mRNA_exp.txt.gz 1.9 Mb (ftp)(http) TXT
GSE120801_miRNA_exp.txt.gz 11.5 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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