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Series GSE121086 Query DataSets for GSE121086
Status Public on Dec 31, 2018
Title Comparison of DNA methyltransferase-1 (Dnmt1) deleted urogenital sinus epithelium compared to wildtype urogenital sinus epithelium
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Dnmt1 is an important regulator of tissue development and differentiation. To assess the effects of epithelium Dnmt1 deletion in the developing urogenital sinus (precursor of the urethra and prostate in males), we isolated urogenital sinus epithelial tissue from Dnmt1 deleted mouse embryos and wildtype mouse embryos. The transcriptomes were analyzed by RNA-seq
Overall design A Shh cre driver was used to achieve Dnmt1 deletion in the epithelium of the developing urogenital sinus. Epithelium of the urogenital sinus of embryonic day 15.5 mouse embryos were isolated by trypsin digestion. Tissues from Dnmt1 mutants (Dnmt1cKO) were compared to wildtype embryos (Control) in this experiment.
Contributor(s) Joseph DB, Vezina CM, Chu L
Citation(s) 30659795
Submission date Oct 10, 2018
Last update date Apr 01, 2019
Contact name Chad Michael Vezina
Organization name University of Wisconsin-Madison
Department Comparative Biosciences
Street address 1656 Linden Drive
City Madison
State/province WI
ZIP/Postal code 53706
Country USA
Platforms (1)
GPL21493 Illumina HiSeq 3000 (Mus musculus)
Samples (12)
GSM3425835 Control_urogenital epithelium_1
GSM3425836 Control_urogenital epithelium_2
GSM3425837 Control_urogenital epithelium_3
BioProject PRJNA495601
SRA SRP164916

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Supplementary file Size Download File type/resource
GSE121086_DBJoseph_GEO_12samples_EC.txt.gz 379.5 Kb (ftp)(http) TXT
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