|
| Status |
Public on Dec 27, 2018 |
| Title |
Metabolic heterogeneity underlies reciprocal fates of TH17 cell stemness and plasticity [ATAC-seq] |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
TH17 cells in autoimmune disease are functionally and metabolically heterogeneous and contain a subset with stemness-associated features but lower anabolic metabolism and a reciprocal subset with higher metabolic activity that supports the transdifferentiation into TH1 cells.
|
| |
|
| Overall design |
ATAC seq of TCRb+YFP+ cells from spleen and draining lymph node in Rptor deficient and wild type cells.
|
| |
|
| Contributor(s) |
Karmaus PW, Chi H, Chen X, Dhungana Y |
| Citation(s) |
30568299 |
| |
| Submission date |
Oct 22, 2018 |
| Last update date |
Mar 19, 2019 |
| Contact name |
Hongbo Chi |
| E-mail(s) |
hongbo.chi@stjude.org
|
| Organization name |
St Jude Children's Research Hospital
|
| Department |
Immunology
|
| Street address |
262 Danny Thomas Place
|
| City |
Memphis |
| State/province |
TN |
| ZIP/Postal code |
38105 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
|
| Samples (18)
|
|
| This SubSeries is part of SuperSeries: |
| GSE121599 |
Metabolic heterogeneity underlies reciprocal fates of TH17 cell stemness and plasticity |
|
| Relations |
| BioProject |
PRJNA497861 |
| SRA |
SRP166317 |
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