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Series GSE121805 Query DataSets for GSE121805
Status Public on Oct 26, 2018
Title Genetic Study of anti-EGFR Antibody Therapy Response in Colorectal Carcinoma
Organism Homo sapiens
Experiment type Genome variation profiling by array
Summary Metastatic colorectal carcinoma is one of the most common cancers in the world, second most commonly diagnosed cancer in Europe. Approximately 25% of patients initially diagnosed with colorectal carcinoma have metastases at the time of the first diagnosis and almost 50% of the diagnosed patients develop metastases, which explains the high mortality rate of these tumors. The carcinogenic process can be inhibited by the inactivation of EGFR receptors, making them important therapeutic targets. However, around 90-80% of patients do not respond to the EGFR targeted therapy. Resistance is mainly due to KRAS gene mutations.
In this study, we built a 171 mutations panel (OncoAlvo®) that screens all mutations recommended by the ESMO, ASCO & NICE Medical Guidelines with 99% accuracy. The samples were simultaneously genotyped by other techniques to validate our panel and accuracy.
Overall design 457 human colorectal samples were genotyped for 171 somatic mutations (by the analysis of 61 positions) in 6 genes. 10 negative sample controls were used. 10 positive sample controls were used. All samples were genotyped by other technologies. The baseline threshold for the measure of the variants were set up with 96 normal samples.
Contributor(s) Vazão H, Luís D, Caldas J, Antunes G, Freitas A, Santos S
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Submission date Oct 25, 2018
Last update date Oct 27, 2018
Contact name Helena Vazao
Organization name HeartGenetics
Department HeartGenetics
Lab lab
Street address Biocant Park Nucleo4, 4A
City Cantanhede
ZIP/Postal code 3060-197
Country Portugal
Platforms (1)
GPL25722 Onco_Agena
Samples (553)
GSM3446428 Patient 1 4181
GSM3446429 Patient 2 4182
GSM3446430 Patient 3 4183
BioProject PRJNA498496

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE121805_G1104129.xml.gz 2.6 Mb (ftp)(http) XML
GSE121805_G1104129_processed.txt.gz 2.3 Kb (ftp)(http) TXT
GSE121805_G1104131.xml.gz 2.6 Mb (ftp)(http) XML
GSE121805_G1104148.xml.gz 2.6 Mb (ftp)(http) XML
GSE121805_G1116205.xml.gz 1.3 Mb (ftp)(http) XML
GSE121805_G1116205_processed.txt.gz 1.6 Kb (ftp)(http) TXT
GSE121805_G1116574.xml.gz 2.7 Mb (ftp)(http) XML
GSE121805_G1116574_processed.txt.gz 2.5 Kb (ftp)(http) TXT
GSE121805_G1116577.xml.gz 2.6 Mb (ftp)(http) XML
GSE121805_G1116577_processed.txt.gz 2.6 Kb (ftp)(http) TXT
GSE121805_G1129200.xml.gz 2.7 Mb (ftp)(http) XML
GSE121805_G1129200_processed.txt.gz 2.6 Kb (ftp)(http) TXT
GSE121805_G1129619.xml.gz 2.6 Mb (ftp)(http) XML
GSE121805_G1129619_processed.txt.gz 2.7 Kb (ftp)(http) TXT
GSE121805_G1135675.xml.gz 2.7 Mb (ftp)(http) XML
GSE121805_G1135675_processed.txt.gz 2.9 Kb (ftp)(http) TXT
GSE121805_G1135819.xml.gz 2.8 Mb (ftp)(http) XML
GSE121805_G1135819_processed.txt.gz 2.1 Kb (ftp)(http) TXT
GSE121805_G1135909.xml.gz 2.7 Mb (ftp)(http) XML
GSE121805_G1135909_processed.txt.gz 2.7 Kb (ftp)(http) TXT
GSE121805_G1139506.xml.gz 2.7 Mb (ftp)(http) XML
GSE121805_G1139506_processed.txt.gz 2.3 Kb (ftp)(http) TXT
GSE121805_G1140105.xml.gz 2.0 Mb (ftp)(http) XML
GSE121805_G1140105_processed.txt.gz 1.4 Kb (ftp)(http) TXT
GSE121805_G1156558.xml.gz 381.0 Kb (ftp)(http) XML
GSE121805_G1156558_processed.txt.gz 1.3 Kb (ftp)(http) TXT
GSE121805_Processed_Results_OncoAlvo.xlsx 17.0 Kb (ftp)(http) XLSX
GSE121805_RAW.tar 10.0 Kb (http)(custom) TAR
GSE121805_S0062445.xml.gz 628.8 Kb (ftp)(http) XML
GSE121805_S0062445_processed.txt.gz 1.4 Kb (ftp)(http) TXT
GSE121805_S0075587.xml.gz 343.2 Kb (ftp)(http) XML
GSE121805_S0075587_processed.txt.gz 1.1 Kb (ftp)(http) TXT
Processed data are available on Series record

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