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| Status |
Public on Nov 26, 2019 |
| Title |
Hypomethylation of STAT1 and HLA-DRB1 is associated with type-I interferon-dependent HLA-DRB1 expression in lupus CD8+ T cells |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by array
|
| Summary |
Systemic lupus erythematosus (SLE) is a chronic relapsing autoimmune disease characterized by the production of autoantibodies and multiple organ involvement. In this study, we investigated genome-wide DNA methylation changes in the CD8+ T cells from 8 pairs of lupus patients compared to age, sex, and ethnicity matched healthy controls.
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| Overall design |
Illumina Infinium MethylationEPIC array of genomic DNA from CD8+T cells extracted from whole blood from 8 systemic lupus erythematosus (SLE) patients and 8 healthy controls (CON) matched by age, sex and ethnicity.
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| |
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| Contributor(s) |
Sawalha AH, Coit P |
| Citation(s) |
30674474 |
| |
| Submission date |
Nov 27, 2018 |
| Last update date |
Dec 10, 2019 |
| Contact name |
Amr Sawalha |
| E-mail(s) |
asawalha@pitt.edu
|
| Organization name |
University of Pittsburgh
|
| Street address |
4401 Penn Avenue
|
| City |
Pittsburgh |
| State/province |
PA |
| ZIP/Postal code |
15224 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL23976 |
Illumina Infinium HumanMethylation850 BeadChip |
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| Samples (16)
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| Relations |
| BioProject |
PRJNA507239 |
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