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| Status |
Public on Dec 31, 2019 |
| Title |
Transcriptomic analysis of gefitinib-resistant EGFR-mutant NSCLC cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
We have employed a transcriptomic approach to find a molecular target that could compensate for the loss of EGFR signaling in NSCLC cell lines with acquired resistance to gefitinib with an EMT phenotype.
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| Overall design |
Total RNA obtained from EGFR-mutant HCC4006 lung adenocarcinoma cells treated with increasing concentrations of gefitinib for 6 months (gefitinib resistant, GER), alone or in combination with the TGFB receptor inhibitor SB431542.
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| Contributor(s) |
Carretero J, Shimamura T |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Nov 28, 2018 |
| Last update date |
Jan 01, 2020 |
| Contact name |
Julian Carretero |
| E-mail(s) |
julian.carretero@uv.es
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| Organization name |
University of Valencia
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| Department |
Physiology
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| Lab |
Molecular Therapies
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| Street address |
Ave. Vicent Andres Estelles s/n
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| City |
Burjassot |
| State/province |
Valencia |
| ZIP/Postal code |
46100 |
| Country |
Spain |
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| Platforms (1) |
| GPL10904 |
Illumina HumanHT-12 V4.0 expression beadchip (gene symbol) |
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| Samples (9)
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| GSM3494553 |
HCC4006 cells, gefitinib resistant, rep 1 |
| GSM3494554 |
HCC4006 cells, gefitinib resistant, rep 2 |
| GSM3494555 |
HCC4006 cells, gefitinib resistant, rep 3 |
| GSM3494556 |
HCC4006 cells, gefitinib resistant, TGFBR inhibitor treated, rep1 |
| GSM3494557 |
HCC4006 cells, gefitinib resistant, TGFBR inhibitor treated, rep2 |
| GSM3494558 |
HCC4006 cells, gefitinib resistant, TGFBR inhibitor treated, rep3 |
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| Relations |
| BioProject |
PRJNA507434 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE123066_RAW.tar |
14.4 Mb |
(http)(custom) |
TAR (of IDAT) |
| Processed data included within Sample table |
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