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Series GSE123823 Query DataSets for GSE123823
Status Public on Jan 01, 2019
Title Transcriptional changes associated with advancing stages of heart failure underlie atrial and ventricular arrhythmogenesis underlie atrial and ventricular arrhythmogenesis
Organism Canis lupus familiaris
Experiment type Expression profiling by array
Summary Heart failure (HF) is a leading cause of mortality and is associated with cardiac remodeling. Vulnerability to atrial fibrillation (AF) has been shown to be greater in the early stages of HF, whereas ventricular tachycardia/fibrillation develop during late stages. Here, we explore changes in gene expression that underlie the differential development of fibrosis and structural alterations that predispose to atrial and ventricular arrhythmias.
 
Overall design RNA from canine right atria (RA) and right ventricle (RV) from controls and ventricular tachypaced to generate heart failure (HF) at early stages (2 weeks) and late stages (5 week) was isolated and gene expression was analysed by the Affymetrix (Canine_2 canFam2) chip (triplicates)
 
Contributor(s) Argenziano M
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Dec 13, 2018
Last update date Jan 03, 2019
Contact name Mariana Alejandra Argenziano
E-mail(s) argenzianm@email.chop.edu
Phone 3127220666
Organization name Children's Hospital Of Philadelphia
Department Human Genetics
Lab Struan Grant
Street address 3615 Civic Center Blvd
City Philadelphia
State/province Pennsylvania
ZIP/Postal code 19104
Country USA
 
Platforms (1)
GPL3738 [Canine_2] Affymetrix Canine Genome 2.0 Array
Samples (18)
GSM3511988 CONTROL RA biological replicate 1
GSM3511989 CONTROL RA biological replicate 2
GSM3511990 CONTROL RA biological replicate 3
Relations
BioProject PRJNA509928

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE123823_RAW.tar 60.5 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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