GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE125056 Query DataSets for GSE125056
Status Public on May 27, 2020
Title Enhancer Regulation in Kidney Repair [RNA-Seq 2]
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary The endogenous repair process of the mammalian kidney allows rapid recovery after acute kidney injury (AKI) through robust proliferation of tubular epithelial cells. There is currently limited understanding of which transcriptional regulators activate these repair programs and how transcriptional deregulation leads to maladaptive repair. Here we investigate the existence of enhancer dynamics in the regenerating mouse kidney.
Overall design RNA-Seq and ChIP-Seq (H3K27ac, H3K4me3, BRD4, POL2) were performed on samples from repairing kidney cortex 2 days after ischemia/reperfusion injury (IRI) to identify activated genes, transcription factors, enhancer and super-enhancers associated with kidney repair.
Contributor(s) Wilflingseder J, Willi M
Citation(s) 32636391
Submission date Jan 14, 2019
Last update date Jul 13, 2020
Contact name Michaela Willi
Organization name NIH
Department NIDDK
Street address 9000 Rockville Pike
City Bethesda
ZIP/Postal code 20814
Country USA
Platforms (1)
GPL21493 Illumina HiSeq 3000 (Mus musculus)
Samples (8)
GSM3561999 Sample_kidney_SHAM_veh_d2_rep1
GSM3562000 Sample_kidney_SHAM_veh_d2_rep2
GSM3562001 Sample_kidney_SHAM_veh_d2_rep3
This SubSeries is part of SuperSeries:
GSE114294 Enhancer Regulation in Kidney Repair
BioProject PRJNA515053
SRA SRP179074

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE125056_RAW.tar 800.0 Kb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap