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Series GSE125111 Query DataSets for GSE125111
Status Public on Sep 17, 2020
Title TGF-b and Eomesodermin coordinate to maintain CD8+ regulatory T cells and limit spontaneous germinal center reaction
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We are interested in CD8+ regulatory T cells that limit germinal center reactions. We have found that in conditional knockout mice lacking both Tgfbr2 and Eomes expression in mature T cells, CD8+ regulatory T cells are severely defective. RNA-seq analysis was employed to characterize the genome-wide transcriptional changes in CD8+ regulatory T cells.
Overall design CD8+ regulatory T cells were FACS sorted from the spleens of 3-month old naïve WT and Tgfbr2-/-Eomes-/- mice. Total RNA was extracted and subjected to RNA-seq analysis.
Contributor(s) Mishra S, Ma C, Liu Y, Liao W, Lai Z, Zou Y, Chen Y, Zhang N
Citation(s) 32991667
Submission date Jan 15, 2019
Last update date Dec 17, 2020
Contact name YI ZOU
Organization name UTHSA-GCCRI
Street address 8403 Floyd Curl Drive
State/province TX
ZIP/Postal code 78229
Country USA
Platforms (1)
GPL21493 Illumina HiSeq 3000 (Mus musculus)
Samples (2)
GSM3563601 WT CD8+ regulatory T cells
GSM3563602 Tgfbr2-/-Eomes-/- CD8+ regulatory T cells
BioProject PRJNA515265
SRA SRP179612

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE125111_RAW.tar 190.0 Kb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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