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| Status |
Public on Mar 16, 2019 |
| Title |
Transcriptomic atlas of mushroom development reveals conserved genes behind complex multicellularity in fungi [Schizophyllum commune] |
| Organism |
Schizophyllum commune |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The evolution of complex multicellularity has been one of the major transitions in the history of life. In contrast to simple multicellular aggregates of cells, it has evolved only in a handful of lineages, including the animals, embryophytes, red and brown algae and fungi. Despite being a key step towards the evolution of complex organisms, the evolutionary origins and the genetic underpinnings of complex multicellularity are incompletely known. We constructed a reference atlas of mushroom formation based on developmental transcriptome data of six species and comparisons of >200 whole genomes, to elucidate the core genetic program of complex multicellularity and fruiting body development in mushroom-forming fungi (Agaricomycetes). Nearly 300 conserved gene families and >70 functional groups contained developmentally regulated genes from five to six species, covering functions related to fungal cell wall (FCW) remodeling, targeted protein degradation, signal transduction, adhesion and small secreted proteins (including effector-like orphan genes). Several of these families, including F-box proteins, expansin-like proteins, protein kinases, and transcription factors, showed expansions in Agaricomycetes, with from which many convergently expandedwere identified in multicellular plants and/or animals too, assuming convergent solutions to genetic hurdles imposed by complex multicellularity among independently evolved lineages. This study provides a novel entry point to studying mushroom development and complex multicellularity in one of the largest clades of complex eukaryotic organisms.
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| Overall design |
14 samples corresponding to 5 developmental stages were analyzed. Developmental stages contain 2-3 biological replicates.
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| Contributor(s) |
Krizsan K, Almasi E, Merenyi Z, Sahu N, Viragh M, Koszo T, Mondo S, Kiss B, Balint B, Kues U, Barry K, Cseklye J, Hegedus B, Henrissat B, Johnson J, Lipzen A, Ohm RA, Nagy I, Pangilinan J, Yan J, Xiong Y, Grigoriev IV, Hibbett DS, Nagy LG |
| Citation(s) |
30902897 |
| Submission date |
Jan 16, 2019 |
| Last update date |
Jun 17, 2019 |
| Contact name |
Laszlo G. Nagy |
| E-mail(s) |
lnagy@fungenomelab.com
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| Phone |
003662599600
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| Organization name |
Biological Research Centre, Hungarian Academy of Sciences
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| Department |
Institute of Biochemistry, Synthetic and Systems Biology Unit
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| Lab |
Laboratory of Fungal Genomics and Evolution
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| Street address |
Temesvari krt 62
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| City |
Szeged |
| State/province |
Csongrad |
| ZIP/Postal code |
6726 |
| Country |
Hungary |
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| Platforms (1) |
| GPL26056 |
Illumina HiSeq 2500 (Schizophyllum commune) |
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| Samples (14)
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| This SubSeries is part of SuperSeries: |
| GSE125200 |
Transcriptomic atlas of mushroom development reveals conserved genes behind complex multicellularity in fungi |
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| Relations |
| BioProject |
PRJNA515511 |
| SRA |
SRP179769 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE125198_RAW.tar |
5.4 Mb |
(http)(custom) |
TAR (of CSV) |
| GSE125198_SC_RPKM_ExpMatrix.csv.gz |
1.7 Mb |
(ftp)(http) |
CSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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