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Series GSE125256 Query DataSets for GSE125256
Status Public on Apr 05, 2023
Title A landscape of circular RNAs expression in the castration-resistant prostate cancer
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Non-coding RNA profiling by high throughput sequencing
Summary Prostate cancer is one of the major cancers that seriously affect men's health. It has high morbidity and high mortality, but there is still no ideal molecular markers for the diagnosis and prognosis of prostate cancer. Castration-resistant prostate cancer is associated with wide variations in survival. To determine whether differentially expressed circRNAs in plasma exosomes can be used as a novel biomarker for castration-resistant prostate cancer prognosis, we performed high-throughput circRNA sequencing on 15 pairs of plasma exosomes from 30 metastatic castration-resistant prostate cancer patients, with or without early progression, to screen differentially expressed circRNAs.
 
Overall design We performed deep RNA-sequencing on ribosomal-depleted RNA isolated from 15 pairs of plasma exosomes from 30 independent patients with castration-resistant prostate cancer, with or without the presence of metastases, using Illumina X Ten. Patients were paired according to their age and clinical indicators.
 
Contributor(s) Li L, Tao W
Citation(s) 36703078
Submission date Jan 17, 2019
Last update date Apr 05, 2023
Contact name wen tao
E-mail(s) 15627860761@163.com
Phone 15627860761
Organization name The Third Affiliated Hospital, Sun Yat-sen University
Street address Tianhe Road 600
City Guangzhou
ZIP/Postal code 510630
Country China
 
Platforms (1)
GPL20795 HiSeq X Ten (Homo sapiens)
Samples (30)
GSM3567318 metastasis castration-resistant prostate cancer1
GSM3567319 metastasis castration-resistant prostate cancer2
GSM3567320 metastasis castration-resistant prostate cancer3
Relations
BioProject PRJNA515702
SRA SRP179986

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Supplementary file Size Download File type/resource
GSE125256_Processed_data_files.txt.gz 342.9 Kb (ftp)(http) TXT
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