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| Status |
Public on Jan 29, 2019 |
| Title |
RNASeq of trigeminal ganglia of chicken and wild duck species |
| Organisms |
Aix sponsa; Anas platyrhynchos; Oxyura jamaicensis; Gallus gallus; Histrionicus histrionicus; Anas rubripes; Aythya affinis |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
A major challenge in biology is to link cellular and molecular variations with behavioral phenotypes. Here, we approached this by studying somatosensory neurons from a panel of bird species from the family Anatidae, known for their tactile-based foraging behavior. We found that tactile specialists exhibit a proportional expansion of neuronal mechanoreceptors in trigeminal ganglia. The expansion of mechanoreceptors occurs via neurons with intermediately and slowly inactivating mechano-current. Such neurons contain the Piezo2 ion channel, whose expression positively correlates with the expression of factors responsible for the development and function of touch receptors. Conversely, Piezo2 expression negatively correlates with expression of molecules mediating the detection of temperature and pain, suggesting that the expansion of Piezo2-containing mechanoreceptors with prolonged mechano-current occurs at the expense of other types of sensory neurons. Our study reveals a general mechanism of tactile specialization in vertebrates at the level of somatosensory system.
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| Overall design |
High-throughput deep sequencing of the mRNA isolated from trigeminal ganglia of 7 bird species; 3 biological replicates per species; Total of 21 samples.
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| Contributor(s) |
Schneider ER, Anderson EO, Feketa VV, Mastrotto M, Nikolaev YA, Gracheva EO, Bagriantsev SN |
| Citation(s) |
30784581 |
| Submission date |
Jan 28, 2019 |
| Last update date |
Apr 30, 2019 |
| Contact name |
Viktor Feketa |
| E-mail(s) |
viktor.feketa@yale.edu
|
| Organization name |
Yale University
|
| Department |
Cellular & Molecular Physiology
|
| Lab |
Sensory Physiology lab
|
| Street address |
333 Cedar St SHM BE58
|
| City |
New Haven |
| State/province |
CT |
| ZIP/Postal code |
06510 |
| Country |
USA |
| |
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| Platforms (7)
|
| GPL19005 |
Illumina HiSeq 2500 (Gallus gallus) |
| GPL22591 |
Illumina HiSeq 2500 (Anas platyrhynchos) |
| GPL26107 |
Illumina HiSeq 2500 (Anas rubripes) |
| GPL26108 |
Illumina HiSeq 2500 (Oxyura jamaicensis) |
| GPL26109 |
Illumina HiSeq 2500 (Aythya affinis) |
| GPL26110 |
Illumina HiSeq 2500 (Histrionicus histrionicus) |
| GPL26111 |
Illumina HiSeq 2500 (Aix sponsa) |
|
| Samples (21)
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|
| Relations |
| BioProject |
PRJNA517454 |
| SRA |
SRP182673 |
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