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| Status |
Public on Jun 10, 2019 |
| Title |
Coordinating Tissue Regeneration through TGF-β Activated Kinase 1 (TAK1) In-activation and Re-activation |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Our study reveals up-regulation of the TAK1 pathway when compared with the uninjured hindlimb in our model of trauma-induced heterotopic ossification (tHO) consisting of hindlimb Achilles’ tendon transection with dorsal burn injury.
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| |
|
| Overall design |
Using a model of musculoskeletal injury, we sought to determine the role that TGF-β activated kinase 1 (TAK1) signaling has on MSC cellular differentiation and inappropriate tissue formation (heterotopic ossification).
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| |
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| Contributor(s) |
Menon R, Huber A, Levi B |
| Citation(s) |
30786091, 32024825, 32484792 |
| |
| Submission date |
Feb 05, 2019 |
| Last update date |
Jun 08, 2020 |
| Contact name |
Rajasree Menon |
| E-mail(s) |
rajmenon@umich.edu
|
| Phone |
7346159720
|
| Organization name |
University of Michigan
|
| Department |
Department of Computational Medicine and Bioinformatics
|
| Street address |
4544E, MSRB2, Catherine Street, University of Michigan
|
| City |
Ann Arbor |
| State/province |
Michigan |
| ZIP/Postal code |
48109 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
|
| Samples (7)
|
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| Relations |
| BioProject |
PRJNA521049 |
| SRA |
SRP183778 |
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