|
| Status |
Public on Feb 16, 2020 |
| Title |
Transcriptome analysis of the iron regulatory transcription factors in Cryptococcus neoformans in response to iron availability |
| Organism |
Cryptococcus neoformans var. grubii H99 |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Purpose: Understanding the iron-responsive regulatory networks in Cryptococcus neoformans.
Methods: The transcriptome profiles of the wild-type, cir1 mutant and hapX mutant were generated by RNA-seq using Illumina Hiseq, in triplicate. The transcriptome profiles of each mutant was compared with that of the wild-type strain.
Results: The iron-responsive transcription factors, Cir1 and HapX, are major regulators for iron acquisition and metabolism in C. neoformans.
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| |
|
| Overall design |
Transcriptome of each mutant vs. Transcriptome of the wild-type
|
| |
|
| Contributor(s) |
Jung W, Do E, Cho Y, Kronstad JW |
| Citation(s) |
32580959 |
| |
| Submission date |
Feb 08, 2019 |
| Last update date |
Dec 21, 2020 |
| Contact name |
Yong-Joon Cho |
| Organization name |
Seoul National University
|
| Street address |
1 Gwanak-ro, Gwanak-gu
|
| City |
Seoul |
| ZIP/Postal code |
08826 |
| Country |
South Korea |
| |
|
| Platforms (1) |
| GPL21548 |
Illumina HiSeq 2000 (Cryptococcus neoformans var. grubii H99) |
|
| Samples (18)
|
| GSM3596125 |
cir1 mutant that treated iron (sample 1) |
| GSM3596126 |
cir1 mutant that treated iron (sample 2) |
| GSM3596127 |
cir1 mutant that treated iron (sample 3) |
|
| This SubSeries is part of SuperSeries: |
| GSE126314 |
ChIP-Seq and RNA-Seq analysis of the iron regulatory transcription factors in Cryptococcus neoformans in response to iron availability |
|
| Relations |
| BioProject |
PRJNA521527 |
| SRA |
SRP184720 |
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