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GEO help: Mouse over screen elements for information. |
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Status |
Public on Feb 13, 2019 |
Title |
The Secondary Crest Myofibroblast PDGFRa Controls Elastogenesis Pathway via a Secondary Tier of Signaling Networks During Alveogenesis |
Organism |
Mus musculus |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
To compare the gene expression profiles between normal and Pdgfra deficient secondary crest myofibroblasts (SCMF). There was a total of 1808 differentially expressed genes of which 866 increased, while 942 decreased in the Pdgfra deficient SCMFs. The differentially expressed genes are related to multiple functions of SCMFs. Pdgfra plays an important role in multiple functions, especially elastogenesis, of secondary crest myofibroblasts during alveolar formation.
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Overall design |
Profiling of gene expression in GFP+ cells sorted from PN14 lungs dissected from wild type (Gli1creERT:mTmG) and Pdgfra mutant (Gli1creERT:mTmG:Pdgfra-f/f) mouse by deep sequecing using Illumina HiSeq2500.
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Contributor(s) |
Li C, Lee MK, Gao F, Webster S, Di H, Duan J, Yang C, Bhopal N, Pryhubar G, Smith SM, Borok Z, Bellusci S, Minoo P |
Citation(s) |
- Gao F, Li C, Smith SM, Peinado N et al. Decoding the IGF1 signaling gene regulatory network behind alveologenesis from a mouse model of bronchopulmonary dysplasia. Elife 2022 Oct 10;11. PMID: 36214448
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Submission date |
Feb 12, 2019 |
Last update date |
Oct 28, 2022 |
Contact name |
Fremont Gao |
E-mail(s) |
fremontgao@gmail.com
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Organization name |
USC
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Street address |
2011 Zonal Ave, HMR 903
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City |
Los Angeles |
State/province |
California |
ZIP/Postal code |
90033 |
Country |
USA |
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Platforms (1) |
GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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Samples (5)
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Relations |
BioProject |
PRJNA521967 |
SRA |
SRP185713 |
Supplementary file |
Size |
Download |
File type/resource |
GSE126457_17921_17924_vs_17927_17928_19016_02.txt.gz |
1.5 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
Raw data are available in SRA |
Processed data are available on Series record |
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