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Series GSE126457 Query DataSets for GSE126457
Status Public on Feb 13, 2019
Title The Secondary Crest Myofibroblast PDGFRa Controls Elastogenesis Pathway via a Secondary Tier of Signaling Networks During Alveogenesis
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary To compare the gene expression profiles between normal and Pdgfra deficient secondary crest myofibroblasts (SCMF).
There was a total of 1808 differentially expressed genes of which 866 increased, while 942 decreased in the Pdgfra deficient SCMFs. The differentially expressed genes are related to multiple functions of SCMFs.
Pdgfra plays an important role in multiple functions, especially elastogenesis, of secondary crest myofibroblasts during alveolar formation.
 
Overall design Profiling of gene expression in GFP+ cells sorted from PN14 lungs dissected from wild type (Gli1creERT:mTmG) and Pdgfra mutant (Gli1creERT:mTmG:Pdgfra-f/f) mouse by deep sequecing using Illumina HiSeq2500.
 
Contributor(s) Li C, Lee MK, Gao F, Webster S, Di H, Duan J, Yang C, Bhopal N, Pryhubar G, Smith SM, Borok Z, Bellusci S, Minoo P
Citation(s) 36214448
Submission date Feb 12, 2019
Last update date Oct 28, 2022
Contact name Fremont Gao
E-mail(s) fremontgao@gmail.com
Organization name USC
Street address 2011 Zonal Ave, HMR 903
City Los Angeles
State/province California
ZIP/Postal code 90033
Country USA
 
Platforms (1)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
Samples (5)
GSM3602074 17927_WT rep1
GSM3602075 17928_WT rep2
GSM3602076 19016_WT rep3
Relations
BioProject PRJNA521967
SRA SRP185713

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE126457_17921_17924_vs_17927_17928_19016_02.txt.gz 1.5 Mb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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