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Status |
Public on Feb 13, 2019 |
Title |
Chaetocin Mediated Changes in Gene Expression Profile of GBM Cells |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
Chaetocin treatment significantly modulated expression profile of GBM cells such that 373 genes were up and 478 genes were down regulated significantly (FDR<0.05). Genes involved in DNA damage response, reactive oxygen species pathway and cell cycle regulation as well as epithelial to mesenchymal transition are significantly modified by Chaetocin, which render GBM cells much more prone to apoptosis.
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Overall design |
Examination of Chaetocin's effect on gene expression profile of U87MG cells. 2 sets of samples were prepared for Chaetocin treated (50 nM, 24h) and untreated (control) conditions.
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Contributor(s) |
Bagci-Onder T, Özyerli-Göknar E, Uyulur F |
Citation missing |
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Submission date |
Feb 12, 2019 |
Last update date |
Mar 21, 2019 |
Contact name |
Tugba Bagci-Onder |
E-mail(s) |
tuonder@ku.edu.tr
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Phone |
+90 212 338 1077
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Organization name |
Koc University
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Department |
School of Medicine
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Lab |
Brain Cancer Research and Therapy Lab
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Street address |
Koc University School of Medicine
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City |
Istanbul |
State/province |
Sariyer |
ZIP/Postal code |
34450 |
Country |
Turkey |
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Platforms (1) |
GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
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Samples (4)
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Relations |
BioProject |
PRJNA521979 |
SRA |
SRP185721 |