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| Status |
Public on Apr 13, 2020 |
| Title |
A TFAP2C Gene Signature is Predictive of Outcome in HER2 Breast Cancer (ChIP-Seq) |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
A subset of HER2 breast cancers with amplification of the TFAP2C gene locus becomes addicted to AP-2g. We sought to define AP-2g-regulated genes that control growth and invasiveness by comparing HER2 cell lines with differential response to TFAP2C knockdown. A set of 68 differentially expressed genes was identified, which included CDH5 and CDKN1A. Pathway analysis implicated the MAPK13/p38δ and retinoic acid regulatory nodes, which were confirmed to display divergent responses. The AP-2g gene signature was highly predictive of outcome in HER2-positive breast cancer patients. We conclude that AP-2g regulates a set of genes in HER2 breast cancer that drive cancer growth and invasiveness and that the AP-2g gene signature can predict outcome of patients with HER2 breast cancer.
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| Overall design |
2 ChIP-Seq data for TFAP2C in human breast carcinoma cell lines SKBR-3 and HCC1954.
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| Contributor(s) |
Wu VT, Kiriazov B, Koch KE, Gu VW, Beck AC, Borcherding N, Li T, Addo P, Wehrspan Z, Zhang W, Braun T, Brown B, Band V, Band H, Kulak MV, Weigel RJ |
| Citation(s) |
31619506 |
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| Submission date |
Feb 21, 2019 |
| Last update date |
Apr 15, 2020 |
| Contact name |
Tiandao Li |
| Organization name |
Washington University
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| Street address |
4444 Forest Park Ave
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| City |
St Louis |
| State/province |
MO |
| ZIP/Postal code |
63108 |
| Country |
USA |
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| Platforms (1) |
| GPL9052 |
Illumina Genome Analyzer (Homo sapiens) |
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| Samples (2) |
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| This SubSeries is part of SuperSeries: |
| GSE126898 |
A TFAP2C Gene Signature is Predictive of Outcome in HER2 Breast Cancer |
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| Relations |
| BioProject |
PRJNA523615 |
| SRA |
SRP186506 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE126897_RAW.tar |
551.0 Mb |
(http)(custom) |
TAR (of WIG) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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