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| Status |
Public on Mar 04, 2019 |
| Title |
Expression profiling of PBMCs from VA-ECLS patients |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We profiled RNA expression by means of single cell RNA-Seq from a total of ~60,000 cells from 38 patients undergoing VA-ECMO due to acute heart failure (including acute exacerbation of chronic failure). Samples were taken at the time of initiation of ECMO (mean +/- 79 minutes from cannulation).
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| Overall design |
Survival analysis, 30 day survival, with cross sectional analysis of gene expression at start of VA-ECLS
Submitters plan to submit raw files to dbGaP to protect patient sequence privacy
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| Contributor(s) |
Kort EJ, Jovinge S |
| Citation |
Eric J. Kort, Matthew Weiland, Edgars Grins, Emily Eugster, Hsiao-yun Milliron, Catherine Kelty, Nabin Manandhar Shrestha, Tomasz Timek, Marzia Leacche, Stephen J Fitch, Theodore J Boeve, Greg Marco, Michael Dickinson, Penny Wilton, Stefan Jovinge. Single cell transcriptomics identifies immunologic priming related to extra corporeal life support survival. bioRxiv 568659; doi:10.1101/568659
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| Submission date |
Feb 26, 2019 |
| Last update date |
Mar 19, 2019 |
| Contact name |
Eric Kort |
| E-mail(s) |
eric.kort@vai.org
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| Phone |
6162345442
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| Organization name |
Van Andel Research Institute
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| Lab |
Jovinge Lab
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| Street address |
333 Bostwick NE
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| City |
Grand Rapids |
| State/province |
MI |
| ZIP/Postal code |
49503 |
| Country |
USA |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (38)
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| Relations |
| BioProject |
PRJNA524362 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE127221_PBMC_merged_filtered_recoded.rds.gz |
170.2 Mb |
(ftp)(http) |
RDS |
| GSE127221_PBMC_merged_filtered_recoded.txt.gz |
116.4 Mb |
(ftp)(http) |
TXT |
| GSE127221_metadata.rds.gz |
1.7 Kb |
(ftp)(http) |
RDS |
| GSE127221_metadata.txt.gz |
791 b |
(ftp)(http) |
TXT |
| Raw data not provided for this record |
| Processed data are available on Series record |
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