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| Status |
Public on Sep 15, 2020 |
| Title |
Yes-Associated Protein (YAP) Induces a Secretome Phenotype and Transcriptionally Regulates Plasminogen Activator Inhibitor-1 (PAI-1) Expression in Hepatocarcinogenesis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
To investigate how tumour cell-derived YAP is changing the paracrine communication network between tumour cells and non-tumorous cells in hepatocarcinogenesis, the expression and secretion of cytokines, growth factors and chemokines were analysed in transgenic mice with liver-specific and inducible expression of constitutively active human YAP (YAPS127A). Transcriptome analysis of primary isolated hepatocytes revealed that YAP overexpression induced the expression and secretion of many paracrine-acting factors with potential impact on other tumorous or non-tumorous cells (e.g. plasminogen activator inhibitor-1 (PAI-1), C-X-C motif chemokine ligand 13 (CXCL13), CXCL16).
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| Overall design |
6 samples were analyzed, Three samples derived from wt livers, three samples derived from enlarged livers (YapS127A)
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| Contributor(s) |
Thomann S, Breuhahn K |
| Citation(s) |
33097058 |
| Submission date |
Mar 08, 2019 |
| Last update date |
Oct 28, 2020 |
| Contact name |
Carsten Sticht |
| Organization name |
University Heidelberg
|
| Department |
ZMF
|
| Street address |
Theodor-Kutzer-Ufer
|
| City |
Mannheim |
| ZIP/Postal code |
68169 |
| Country |
Germany |
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| Platforms (1) |
| GPL22598 |
[MoGene-2_0-st] Affymetrix Mouse Gene 2.0 ST Array (mogene20st_Mm_ENTREZG_20.0.0) |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE128047 |
An endothelial subtype-specific communication network orchestrates capillarization in liver tumorigenesis via the Hgf/c-Met pathway |
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| Relations |
| BioProject |
PRJNA526204 |
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