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| Status |
Public on Mar 14, 2019 |
| Title |
Drosophila CNS mitochondrial dysfunction with ATF4 inhibition RNA-Seq |
| Organism |
Drosophila melanogaster |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Mitochondrial dysfunction causes biophysical, metabolic and signalling changes that alter homeostasis and reprogram cells. We used a Drosophila model in which TFAM is overexpressed in the nervous system with or without knock-down of the ER UPR transcription factor ATF4, to investigate the how mitochondrial dysfunction and ER stress signalling affect the transcriptome.
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| Overall design |
mRNA profiles of Drosophila CNS with mitochondrial dysfunction, ATF4 overexpression, and mitochondrial dysfunction with ATF4 knock-down were generated by RNA sequencing, in quadruplicate, using the Illumina NextSeq 500.
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| Contributor(s) |
Bateman JM, Hunt RJ |
| Citation(s) |
31645461 |
| |
| Submission date |
Mar 13, 2019 |
| Last update date |
Oct 03, 2022 |
| Contact name |
Joseph Matthew Bateman |
| E-mail(s) |
joseph_matthew.bateman@kcl.ac.uk
|
| Phone |
44-(0)207 848 8144
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| Organization name |
King's College London
|
| Department |
Basic & Clinical Neuroscience
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| Lab |
Maurice Wohl Clinical Neuroscience Institute
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| Street address |
Cutcombe Road
|
| City |
London |
| ZIP/Postal code |
SE5 9RT |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL19132 |
Illumina NextSeq 500 (Drosophila melanogaster) |
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| Samples (16)
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| Relations |
| BioProject |
PRJNA526877 |
| SRA |
SRP188337 |
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