|
| Status |
Public on Aug 08, 2019 |
| Title |
A large panel of isogenic APP and PSEN1 mutant human iPSC neurons reveals shared endosomal abnormalities mediated by APP b-CTFs, not Ab [RNA-seq] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Human iPS cells with different mutations linked to Alzheimer's Disease were differentiated into neurons and subjected to RNAseq to identify Alzheimer's Disease associated changes
|
| |
|
| Overall design |
RNAseq analysis of wildtype and three different mutated human iPS cells differentiated into neurons before
|
| |
|
| Contributor(s) |
Scheckel C, Murphy E, Darnell R, Kwart D, Gregg A, Tessier-Lavigne M |
| Citation(s) |
31416668 |
| Submission date |
Mar 15, 2019 |
| Last update date |
Mar 06, 2021 |
| Contact name |
Claudia Scheckel |
| E-mail(s) |
claudia.scheckel@gmail.com
|
| Organization name |
University Hospital Zurich
|
| Department |
Institute of Neuropathology
|
| Street address |
Schmelzbergstrasse 12
|
| City |
Zurich |
| State/province |
NY |
| ZIP/Postal code |
8091 |
| Country |
Switzerland |
| |
|
| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
|
| Samples (12)
|
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| This SubSeries is part of SuperSeries: |
| GSE128345 |
A large panel of isogenic APP and PSEN1 mutant human iPSC neurons reveals shared endosomal abnormalities mediated by APP b-CTFs, not Ab |
|
| Relations |
| BioProject |
PRJNA527202 |
| SRA |
SRP188499 |
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