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Series GSE128883 Query DataSets for GSE128883
Status Public on Nov 21, 2019
Title Altered chromatin remodeling by FOXA1 mutations promotes androgen independence and prostate cancer aggressiveness [ChIP-seq]
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary FKHD-mutant (FKHDm) FOXA1 has impaired ability to bind chromatin and thus failed to rescue wildtype FOXA1-mediated transcriptional program. FKHDm FOXA1 formed much stronger interaction with the AR protein, thereby preventing AR from binding to the chromatin.
 
Overall design ChIP-seq examination of AR and FOXA1 (HA-tag) binding sites in LNCaP shCtr and shFOXA1 cells with overexpressed FOXA1 wildtype or various FOXA1 mutants in the presence or absence of androgen.
 
Contributor(s) Yu J, Xu B, Song B, Lu X
Citation(s) 31324884
Submission date Mar 26, 2019
Last update date Feb 20, 2020
Contact name Jindan Yu
E-mail(s) jindan.yu@emory.edu
Organization name Emory University
Department Urology
Lab Jindan Yu's lab
Street address E330, 1760 Haygood Dr NE
City Atlanta
State/province GA
ZIP/Postal code 30322
Country USA
 
Platforms (1)
GPL15456 Illumina HiScanSQ (Homo sapiens)
Samples (36)
GSM3687942 m299_ChIP-seq_LNCap +R GFP+pGIPZ
GSM3687943 m300_ChIP-seq_LNCap +R GFP+pGIPZ shFoxA1
GSM3687944 m310_ChIP-seq_LNCap +R WT+pGIPZ shFoxA1
This SubSeries is part of SuperSeries:
GSE128884 Altered chromatin remodeling by FOXA1 mutations promotes androgen independence and prostate cancer aggressiveness
Relations
BioProject PRJNA529211
SRA SRP189491

Download family Format
SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE128883_RAW.tar 1.5 Gb (http)(custom) TAR (of BEDGRAPH, TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file
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