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Series GSE129034 Query DataSets for GSE129034
Status Public on Oct 11, 2019
Title Comparison of chromatin accessibility between human and non-human primates
Organisms Macaca mulatta; Gorilla gorilla; Pan troglodytes; Pongo pygmaeus; Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Evolution of transcriptional regulation is thought to be a major cause of the evolution of phenotypic traits. We compared DNase I Hypersensitive sites in fibroblast cells from five primates (human, chimpanzee, gorilla, orangutan, and macaque). We identified approximately 90,000 DHS sites, of which 59% are not significantly different between species, 27% are differential and likely due to a single evolutionary change, and 14% are differential and likely due to multiple changes. We found that including additional closely related species allows us to better distinguish between accessibility changes that are specific to a single species and those that have experienced changes in chromatin accessibility across multiple species during evolution.
Overall design DNase-seq of 3 biological replicates from each of 5 species: human, chimpanzee, gorilla, orangutan, and macaque.

Grant ID: HOMINID 0827552
Funding source: NSF
Grant title: Genetic Bases for the Evolution of Human Diet
Grantee name: Gregory Wray
Contributor(s) Crawford G, Wray G
Citation(s) 31599933
Submission date Mar 29, 2019
Last update date Oct 21, 2019
Contact name Gregory Crawford
Organization name Duke University
Street address 101 Science Drive
City Durham
State/province NC
ZIP/Postal code 27708
Country USA
Platforms (7)
GPL9115 Illumina Genome Analyzer II (Homo sapiens)
GPL9160 Illumina Genome Analyzer II (Macaca mulatta)
GPL9378 Illumina Genome Analyzer II (Pan troglodytes)
Samples (15)
GSM3691993 Human replicate 1
GSM3691994 Human replicate 2
GSM3691995 Human replicate 3
BioProject PRJNA529812
SRA SRP189858

Download family Format
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Supplementary file Size Download File type/resource
GSE129034_RAW.tar 7.2 Gb (http)(custom) TAR (of BED)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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